CRY1
| Gene Symbol | CRY1 |
|---|---|
| Entrez Gene | 1407 |
| Alt Symbol | PHLL1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cryptochrome circadian clock 1 |
| Other Description | cryptochrome 1 (photolyase-like)|cryptochrome-1 |
| Swissprots | Q16526 |
| Accessions | ABM64209 EAW97795 EAW97796 EAW97797 Q16526 AK098615 BAC05354 AK125915 AK290552 BAF83241 BC017466 BC030519 AAH30519 BJ993835 D83702 BAA12068 D84657 BAA12710 DB454192 JF432699 ADZ15916 XM_011537939 XP_011536241 NM_004075 NP_004066 |
| Function | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and |
| Subcellular Location | Cytoplasm. Nucleus {ECO:0000250|UniProtKB:P97784}. Note=Translocated to the nucleus through interaction with other clock proteins such as PER2 or ARNTL/BMAL1. {ECO:0000250}. |
| Top Pathways | Circadian rhythm |
CRY1 (H-12) - sc-393466 from Santa Cruz Biotechnology
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CRY1 (A-20) - sc-5953 from Santa Cruz Biotechnology
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CRY1 (H-84) - sc-33177 from Santa Cruz Biotechnology
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CRY1 (W-L5) - sc-101006 from Santa Cruz Biotechnology
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Anti-Cryptochrome I antibody - ab54649 from Abcam
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Anti-CRY1 Antibody (aa571-586) - LS-C3018 from LifeSpan Bioscience
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Anti-CRY1 Antibody (C-Terminus) - LS-C6226 from LifeSpan Bioscience
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Anti-CRY1 Antibody (C-Terminus) - LS-C6227 from LifeSpan Bioscience
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Anti-CRY1 Antibody (C-Terminus) - LS-C22439 from LifeSpan Bioscience
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Anti-CRY1 Antibody (aa1-587) - LS-C36020 from LifeSpan Bioscience
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Anti-CRY1 Antibody (aa115-224) - LS-C36021 from LifeSpan Bioscience
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Anti-CRY1 Antibody (C-Terminus) - LS-C125412 from LifeSpan Bioscience
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Anti-CRY1 Antibody - LS-C150107 from LifeSpan Bioscience
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Anti-CRY1 Antibody (clone 3551C4a) - LS-C184765 from LifeSpan Bioscience
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Anti-CRY1 Antibody (C-Terminus, FITC) - LS-C276514 from LifeSpan Bioscience
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Anti-CRY1 Antibody (C-Terminus, Biotin) - LS-C276513 from LifeSpan Bioscience
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Anti-CRY1 Antibody (C-Terminus, APC) - LS-C276512 from LifeSpan Bioscience
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Anti-CRY1 Antibody (C-Terminus, AP) - LS-C276511 from LifeSpan Bioscience
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Anti-CRY1 Antibody (C-Terminus, PE) - LS-C276516 from LifeSpan Bioscience
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Anti-CRY1 Antibody (C-Terminus, Azide-free, HRP) - LS-C276515 from LifeSpan Bioscience
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Anti-CRY1 Antibody (aa536-586) - LS-C289345 from LifeSpan Bioscience
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Anti-CRY1 Antibody (C-Terminus) - LS-C327130 from LifeSpan Bioscience
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Anti-CRY1 Antibody (aa551-555) - LS-C205380 from LifeSpan Bioscience
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Anti-CRY1 Antibody (C-Terminus) - LS-C100382 from LifeSpan Bioscience
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Anti-CRY1 Antibody (clone 3551C4a) - LS-C342789 from LifeSpan Bioscience
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