| Gene Symbol | CRY1 |
|---|---|
| Entrez Gene | 1407 |
| Alt Symbol | PHLL1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cryptochrome circadian clock 1 |
| Other Description | cryptochrome 1 (photolyase-like)|cryptochrome-1 |
| Swissprots | Q16526 |
| Accessions | ABM64209 EAW97795 EAW97796 EAW97797 Q16526 AK098615 BAC05354 AK125915 AK290552 BAF83241 BC017466 BC030519 AAH30519 BJ993835 D83702 BAA12068 D84657 BAA12710 DB454192 JF432699 ADZ15916 XM_011537939 XP_011536241 NM_004075 NP_004066 |
| Function | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and |
| Subcellular Location | Cytoplasm. Nucleus {ECO:0000250|UniProtKB:P97784}. Note=Translocated to the nucleus through interaction with other clock proteins such as PER2 or ARNTL/BMAL1. {ECO:0000250}. |
| Top Pathways | Circadian rhythm |
CRY1 CRISPR/Cas9 KO Plasmid (h) - sc-400946 from Santa Cruz Biotechnology
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CRY1 HDR Plasmid (h) - sc-400946-HDR from Santa Cruz Biotechnology
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CRY1 Double Nickase Plasmid (h) - sc-400946-NIC from Santa Cruz Biotechnology
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CRY1 Double Nickase Plasmid (h2) - sc-400946-NIC-2 from Santa Cruz Biotechnology
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CRY1 CRISPR Activation Plasmid (h) - sc-400946-ACT from Santa Cruz Biotechnology
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CRY1 CRISPR Activation Plasmid (h2) - sc-400946-ACT-2 from Santa Cruz Biotechnology
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CRY1 Lentiviral Activation Particles (h) - sc-400946-LAC from Santa Cruz Biotechnology
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CRY1 Lentiviral Activation Particles (h2) - sc-400946-LAC-2 from Santa Cruz Biotechnology
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CRY1 siRNA (h) - sc-43706 from Santa Cruz Biotechnology
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CRY1 shRNA Plasmid (h) - sc-43706-SH from Santa Cruz Biotechnology
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CRY1 shRNA (h) Lentiviral Particles - sc-43706-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU071711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6601 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05681 from Sigma-Aldrich
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CRY1 siRNA (Human) - CRH0989 from Cohesion Biosciences
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CRY1 RNAi - H00001407-R02 from Novus Biologicals
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CRY1 - MBS8200399 from MyBioSource
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shRNA set against Human CRY1 (NM_004075.4) - SHH269873 from Creative biogene
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Human CRY1 siRNA - orb261491 from Biorbyt
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CRY1 shRNA Plasmid (Human) - CHH0989 from Cohesion Biosciences
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CRY1 miRNA 3'UTR clone - MiUTR3H-04516 from Creative biogene
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