| Gene Symbol |
TIMELESS
|
| Entrez Gene |
8914
|
| Alt Symbol |
TIM, TIM1, hTIM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
timeless circadian clock
|
| Other Description |
Tof1 homolog|protein timeless homolog|timeless circadian clock 1|timeless homolog
|
| Swissprots |
Q8IWH3 Q86VM1 Q9UNS1 O94802 B2ZAV0
|
| Accessions |
ACD11488 EAW96939 Q9UNS1 AB015597 BAA36499 AF098162 AAC80011 AK000721 AK022702 BAG51106 AK296869 BAG59432 AY207390 BC031514 BC039842 AAH39842 BC050557 AAH50557 BE503292 BP363571 BX640990 CAE45996 XM_011538939 XP_011537241 NM_003920 NP_003911
|
| Function |
Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an importa
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:17141802}.
|
| Tissue Specificity |
Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus and testis. {ECO:0000269|PubMed:9856465, ECO:0000269|PubMed:9891984}.
|