TIMELESS

Gene Symbol	TIMELESS
Entrez Gene	8914
Alt Symbol	TIM, TIM1, hTIM
Species	Human
Gene Type	protein-coding
Description	timeless circadian clock
Other Description	Tof1 homolog|protein timeless homolog|timeless circadian clock 1|timeless homolog
Swissprots	Q8IWH3 Q86VM1 Q9UNS1 O94802 B2ZAV0
Accessions	ACD11488 EAW96939 Q9UNS1 AB015597 BAA36499 AF098162 AAC80011 AK000721 AK022702 BAG51106 AK296869 BAG59432 AY207390 BC031514 BC039842 AAH39842 BC050557 AAH50557 BE503292 BP363571 BX640990 CAE45996 XM_011538939 XP_011537241 NM_003920 NP_003911
Function	Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an importa
Subcellular Location	Nucleus {ECO:0000269|PubMed:17141802}.
Tissue Specificity	Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus and testis. {ECO:0000269|PubMed:9856465, ECO:0000269|PubMed:9891984}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Timeless protein fragment - ab160263 from Abcam Category Protein Source Wheat germ Species Human

Timeless peptide - ab113078 from Abcam Category Peptide

TIMELESS Antibody Blocking Peptide - LS-E12097 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TIMELESS Antibody Blocking Peptide - LS-E13797 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Timeless Protein - H00008914-Q01 from Novus Biologicals Category Protein Prices $319.00, $369.00, $529.00 Sizes 2 µg, 10 µg, 25 µg Source Wheat Germ Species Human

TIMELESS Blocking Peptide - 33R-5848 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TIMELESS Blocking Peptide - 33R-3969 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TIMELESS Blocking Peptide - 33R-2343 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TIMELESS - H00008914-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TIMELESS - H00008914-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TIMELESS fusion protein - Ag6283 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

TIMELESS fusion protein - Ag5767 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human TIMELESS, His-tagged - TIMELESS-3233H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Protein timeless homolog(TIMELESS) ,partial - CSB-YP892360HU CSB-EP892360HU CSB-BP892360HU CSB-MP892360HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Timeless (Tim) - TP308527 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Timeless Recombinant Protein Antigen - NBP2-32559PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TIMELESS Peptide, Human - M34GP15955H from Creative Peptides Category Peptide Source Synthetic. Species Human

Protein timeless homolog (848-856) - ta-059 from Creative Peptides Category Protein Source Homo sapiens (human)

Protein timeless homolog (TIMELESS), partial, Recombinant Protein - MBS1367335 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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