| Gene Symbol |
CENPW
|
| Entrez Gene |
387103
|
| Alt Symbol |
C6orf173, CENP-W, CUG2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
centromere protein W
|
| Other Description |
cancer-up-regulated gene 2 protein|cancer-upregulated gene 2
|
| Swissprots |
A6NIR0 Q5EE01 A6NJC2
|
| Accessions |
CAF17861 EAW48119 EAW48120 EAW48121 EAW48122 EAW48123 Q5EE01 AI207187 AL832235 AY902475 AAW82474 BC017928 AAH17928 BC039556 AAH39556 BC046178 AAH46178 BC062798 AAH62798 BM721156 BM874602 NM_001012507 NP_001012525 NM_001286524 NP_001273453 NM_001286525 NP_001273454 NR_104462
|
| Function |
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000250, ECO:0000269|PubMed:19070575, ECO:0000269|PubMed:19533040, ECO:0000269|PubMe
|
| Subcellular Location |
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Nucleus matrix. Nucleus, nucleolus. Note=Constitutively localizes to centromeres throughout the cell cycle, and to the inner kinetochore during mitosis.
|
| Tissue Specificity |
Highly expressed in ovary, liver, lung and pancreas and to a lower extent in breast and gastrointestinal tract cancers; such as those of the colon, rectum and stomach. Overexpressed in high grade breast invasive tumors. Expressed in many cancer cell types. {ECO:0000269|PubMed:17079448, ECO:0000269|PubMed:17610844}.
|