CENPW

Gene Symbol	CENPW
Entrez Gene	387103
Alt Symbol	C6orf173, CENP-W, CUG2
Species	Human
Gene Type	protein-coding
Description	centromere protein W
Other Description	cancer-up-regulated gene 2 protein|cancer-upregulated gene 2
Swissprots	A6NIR0 Q5EE01 A6NJC2
Accessions	CAF17861 EAW48119 EAW48120 EAW48121 EAW48122 EAW48123 Q5EE01 AI207187 AL832235 AY902475 AAW82474 BC017928 AAH17928 BC039556 AAH39556 BC046178 AAH46178 BC062798 AAH62798 BM721156 BM874602 NM_001012507 NP_001012525 NM_001286524 NP_001273453 NM_001286525 NP_001273454 NR_104462
Function	Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000250, ECO:0000269|PubMed:19070575, ECO:0000269|PubMed:19533040, ECO:0000269|PubMe
Subcellular Location	Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Nucleus matrix. Nucleus, nucleolus. Note=Constitutively localizes to centromeres throughout the cell cycle, and to the inner kinetochore during mitosis.
Tissue Specificity	Highly expressed in ovary, liver, lung and pancreas and to a lower extent in breast and gastrointestinal tract cancers; such as those of the colon, rectum and stomach. Overexpressed in high grade breast invasive tumors. Expressed in many cancer cell types. {ECO:0000269|PubMed:17079448, ECO:0000269|PubMed:17610844}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

CUG2 (N-12) - sc-137988 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CUG2 (Q-14) - sc-137989 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-C6ORF173 antibody - ab75827 from Abcam Prices $378.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-C6ORF173 antibody - N-terminal - ab189957 from Abcam Prices $376.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-CENPW / C6orf173 Antibody (N-Terminus) IHC-plus™ - LS-B8844 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-CENPW / C6orf173 Antibody (N-Terminus) - LS-C82777 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

CENPW Antibody - NBP1-70496 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C6ORF173 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-15230R-A350 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C6ORF173 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-15230R-A488 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C6ORF173 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-15230R-A555 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C6ORF173 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-15230R-A647 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C6ORF173 Polyclonal Antibody, Cy3 Conjugated - bs-15230R-Cy3 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C6ORF173 Polyclonal Antibody, Cy5 Conjugated - bs-15230R-Cy5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C6ORF173 Polyclonal Antibody, Cy5.5 Conjugated - bs-15230R-Cy5.5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C6ORF173 Polyclonal Antibody, Cy7 Conjugated - bs-15230R-Cy7 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C6ORF173 Polyclonal Antibody, FITC Conjugated - bs-15230R-FITC from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C6ORF173 Polyclonal Antibody, Biotin Conjugated - bs-15230R-Biotin from Bioss Prices $349.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C6ORF173 Polyclonal Antibody, HRP Conjugated - bs-15230R-HRP from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-C6ORF173 antibody produced in rabbit - AV54417 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CENPW antibody produced in rabbit - SAB3500805 from Sigma-Aldrich Prices $341.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

C6orf173 antibody - N-terminal region (ARP54417_P050) - ARP54417_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C6ORF173 antibody, N-term - GTX45426 from GeneTex Prices $319.00 Sizes 50 μg Host Rabbit Clonality Polyclonal

C6ORF173 antibody - 70R-4208 from Fitzgerald Prices $345.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

C6ORF173 Polyclonal Antibody - bs-15230R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CENP-W antibody - 24509-1-AP from Acris Antibodies Prices $270.00 Sizes 150 µl Host Rabbit Clonality Polyclonal

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