CENPW

Gene Symbol CENPW
Entrez Gene 387103
Alt Symbol C6orf173, CENP-W, CUG2
Species Human
Gene Type protein-coding
Description centromere protein W
Other Description cancer-up-regulated gene 2 protein|cancer-upregulated gene 2
Swissprots A6NIR0 Q5EE01 A6NJC2
Accessions CAF17861 EAW48119 EAW48120 EAW48121 EAW48122 EAW48123 Q5EE01 AI207187 AL832235 AY902475 AAW82474 BC017928 AAH17928 BC039556 AAH39556 BC046178 AAH46178 BC062798 AAH62798 BM721156 BM874602 NM_001012507 NP_001012525 NM_001286524 NP_001273453 NM_001286525 NP_001273454 NR_104462
Function Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000250, ECO:0000269|PubMed:19070575, ECO:0000269|PubMed:19533040, ECO:0000269|PubMe
Subcellular Location Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Nucleus matrix. Nucleus, nucleolus. Note=Constitutively localizes to centromeres throughout the cell cycle, and to the inner kinetochore during mitosis.
Tissue Specificity Highly expressed in ovary, liver, lung and pancreas and to a lower extent in breast and gastrointestinal tract cancers; such as those of the colon, rectum and stomach. Overexpressed in high grade breast invasive tumors. Expressed in many cancer cell types. {ECO:0000269|PubMed:17079448, ECO:0000269|PubMed:17610844}.

CUG2 CRISPR/Cas9 KO Plasmid (h) - sc-417019 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CUG2 HDR Plasmid (h) - sc-417019-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CUG2 Double Nickase Plasmid (h) - sc-417019-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CUG2 Double Nickase Plasmid (h2) - sc-417019-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CUG2 CRISPR Activation Plasmid (h) - sc-417019-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CUG2 CRISPR Activation Plasmid (h2) - sc-417019-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CUG2 Lentiviral Activation Particles (h) - sc-417019-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CUG2 Lentiviral Activation Particles (h2) - sc-417019-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CUG2 siRNA (h) - sc-95251 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CUG2 shRNA Plasmid (h) - sc-95251-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CUG2 shRNA (h) Lentiviral Particles - sc-95251-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU103841 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5956 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5956 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00934 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00934

CENPW siRNA (Human) - CRJ7726 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CENPW - MBS8216314 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CENPW (NM_001012507.2) - SHH261773 from Creative biogene

Category siRNA
Species Reactivities Human

CENPW shRNA Plasmid (Human) - CHJ7726 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CENPW miRNA 3'UTR clone - MiUTR3H-11759 from Creative biogene

Species Reactivities Human
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