Gene Symbol | SLC5A12 |
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Entrez Gene | 159963 |
Alt Symbol | SMCT2 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 |
Other Description | electroneutral sodium monocarboxylate cotransporter|low-affinity sodium-lactate cotransporter|sodium-coupled monocarboxylate transporter 2|sodium-iodide related cotransporter|solute carrier family 5 (sodium/glucose cotransporter), member 12|solute carrier family 5 member 12 |
Swissprots | Q1EHB4 Q86UC7 |
Accessions | EAW68293 EAW68294 EAW68295 Q1EHB4 AL049270 AW614338 AY299482 AAQ73572 BC029048 BC041454 AAH41454 BC049207 AAH49207 BM924715 CN370367 CR747563 XM_006718155 XP_006718218 XM_006718156 XP_006718219 XM_006718157 XP_006718220 XM_011519920 XP_011518222 XM_011519921 XP_011518223 XR_930845 NM_178498 NP_848593 |
Function | Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D- hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity). {ECO:0000250}. |
Subcellular Location | Apical cell membrane {ECO:0000269|PubMed:17692818}; Multi-pass membrane protein {ECO:0000269|PubMed:17692818}. Note=Detected at the brush border membrane of the kidney. Colocalizes with viementin in Mueller cells (By similarity). {ECO:0000250}. |
SLC5A12 (G-16) - sc-162217 from Santa Cruz Biotechnology
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SLC5A12 (H-55) - sc-367612 from Santa Cruz Biotechnology
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SLC5A12 (S-17) - sc-162221 from Santa Cruz Biotechnology
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SLC5A12 (P-14) - sc-162220 from Santa Cruz Biotechnology
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Anti-SLC5A12 antibody - ab107749 from Abcam
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SLC5A12 Antibody - NBP1-92408 from Novus Biologicals
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ANTI-SLC5A12 (C-TERM) antibody produced in rabbit - SAB1301106 from Sigma-Aldrich
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Anti-SLC5A12 antibody produced in rabbit - HPA045181 from Sigma-Aldrich
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SLC5A12 antibody - 14391-1-AP from Proteintech Group
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Anti-SLC5A12 monoclonal antibody - DCABH-13512 from Creative Diagnostics
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SLC5A12 (H-4) - sc-515141 from Santa Cruz Biotechnology
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SLC5A12-Antibody-C-term - AP10330b from Abgent, a WuXi AppTec company
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SLC5A12 Antibody - NBP2-49322 from Novus Biologicals
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Anti-SLC5A12 polyclonal antibody - CABT-BL5698 from Creative Diagnostics
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SLC5A12 Antibody - 55-133 from ProSci
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SLC5A12 antibody - C-terminal region (OAAB00337) - OAAB00337 from Aviva Systems Biology
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SLC5A12, Polyclonal Antibody - MBS9217008 from MyBioSource
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