| Gene Symbol |
SLC5A12
|
| Entrez Gene |
159963
|
| Alt Symbol |
SMCT2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
|
| Other Description |
electroneutral sodium monocarboxylate cotransporter|low-affinity sodium-lactate cotransporter|sodium-coupled monocarboxylate transporter 2|sodium-iodide related cotransporter|solute carrier family 5 (sodium/glucose cotransporter), member 12|solute carrier family 5 member 12
|
| Swissprots |
Q1EHB4 Q86UC7
|
| Accessions |
EAW68293 EAW68294 EAW68295 Q1EHB4 AL049270 AW614338 AY299482 AAQ73572 BC029048 BC041454 AAH41454 BC049207 AAH49207 BM924715 CN370367 CR747563 XM_006718155 XP_006718218 XM_006718156 XP_006718219 XM_006718157 XP_006718220 XM_011519920 XP_011518222 XM_011519921 XP_011518223 XR_930845 NM_178498 NP_848593
|
| Function |
Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D- hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Apical cell membrane {ECO:0000269|PubMed:17692818}; Multi-pass membrane protein {ECO:0000269|PubMed:17692818}. Note=Detected at the brush border membrane of the kidney. Colocalizes with viementin in Mueller cells (By similarity). {ECO:0000250}.
|