Gene Symbol | HEY1 |
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Entrez Gene | 23462 |
Alt Symbol | BHLHb31, CHF2, HERP2, HESR1, HRT-1, OAF1, hHRT1 |
Species | Human |
Gene Type | protein-coding |
Description | hes-related family bHLH transcription factor with YRPW motif 1 |
Other Description | HES-related repressor protein 1|HES-related repressor protein 2|basic helix-loop-helix protein OAF1|cardiovascular helix-loop-helix factor 2|class B basic helix-loop-helix protein 31|hairy and enhancer of split-related protein 1|hairy-related transcription factor 1|hairy/enhancer-of-split related with YRPW motif 1|hairy/enhancer-of-split related with YRPW motif protein 1 |
Swissprots | Q5TZS3 Q9NYP4 Q9Y5J3 Q8NAM2 B2R883 |
Accessions | CAB90212 EAW87066 Q9Y5J3 AF151522 AAD38967 AF176422 AAD51749 AF232239 AAF37297 AF254637 AAL06278 AF311883 AAG31156 AJ272214 CAB75715 AK074641 BAG51980 AK092437 BAC03890 AK226041 AK293646 BAG57100 AK307622 AK313271 BAG36080 BC001873 AAH01873 BP283540 BT020065 AAV38868 DA561783 JF432799 ADZ16016 R61374 NM_001040708 NP_001035798 NM_012258 NP_036390 NM_001282851 NP_001269780 |
Function | Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'- CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. {ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:15485867}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}. |
Tissue Specificity | Expressed in the somitic mesoderm, the central nervous system, the kidney, the heart, nasal epithelium, and limbs. |
HRT1 CRISPR/Cas9 KO Plasmid (h) - sc-402265 from Santa Cruz Biotechnology
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HRT1 HDR Plasmid (h) - sc-402265-HDR from Santa Cruz Biotechnology
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HRT1 Double Nickase Plasmid (h) - sc-402265-NIC from Santa Cruz Biotechnology
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HRT1 Double Nickase Plasmid (h2) - sc-402265-NIC-2 from Santa Cruz Biotechnology
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HRT1 CRISPR Activation Plasmid (h) - sc-402265-ACT from Santa Cruz Biotechnology
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HRT1 CRISPR Activation Plasmid (h2) - sc-402265-ACT-2 from Santa Cruz Biotechnology
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HRT1 Lentiviral Activation Particles (h) - sc-402265-LAC from Santa Cruz Biotechnology
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HRT1 Lentiviral Activation Particles (h2) - sc-402265-LAC-2 from Santa Cruz Biotechnology
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HRT1 siRNA (h) - sc-37914 from Santa Cruz Biotechnology
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HRT1 shRNA Plasmid (h) - sc-37914-SH from Santa Cruz Biotechnology
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HRT1 shRNA (h) Lentiviral Particles - sc-37914-V from Santa Cruz Biotechnology
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HEY1 RNAi - H00023462-R01 from Novus Biologicals
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MISSION® esiRNA - EHU092701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10005 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10005 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09008 from Sigma-Aldrich
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HEY1 siRNA (Human) - CRH8284 from Cohesion Biosciences
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HEY1 - MBS8217570 from MyBioSource
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shRNA set against Human HEY1 (NM_012258.3) - SHH311825 from Creative biogene
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shRNA set against Human HEY1(NM_001040708.1) - SHH119297 from Creative biogene
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shRNA set against Human HEY1(NM_012258.3) - SHH119333 from Creative biogene
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Human HEY1 siRNA - orb268786 from Biorbyt
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HEY1 shRNA Plasmid (Human) - CHH8284 from Cohesion Biosciences
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HEY1 miRNA 3'UTR clone - MiUTR1H-04472 from Creative biogene
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HEY1 miRNA 3'UTR clone - MiUTR1H-04473 from Creative biogene
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