CMKLR1

Gene Symbol	CMKLR1
Entrez Gene	1240
Alt Symbol	CHEMERINR, ChemR23, DEZ, RVER1
Species	Human
Gene Type	protein-coding
Description	chemerin chemokine-like receptor 1
Other Description	G-protein coupled receptor ChemR23\|G-protein coupled receptor DEZ\|chemerin receptor\|chemokine receptor-like 1\|chemokine-like receptor 1\|orphan G-protein coupled receptor, Dez\|resolvin E1 receptor
Swissprots	Q99788 A8K6Y5 Q5U0H0 Q3KP37 O75748 Q99789
Accessions	AAQ62778 BAC06089 CAA75112 EAW97810 EAW97811 Q99788 AB112777 BAF34667 AK126405 AK291800 BAF84489 AY497547 AAR90850 BC106927 AAI06928 BC106928 AAI06929 BP328503 BT019556 AAV38363 BT019557 AAV38364 DA466082 DA939526 U79526 AAC51258 U79527 AAC51259 NM_001142343 NP_001135815 NM_001142344 NP_001135816 NM_001142345 NP_001135817 NM_004072 NP_004063
Function	Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). {ECO:0000269\|PubMed:15728234, ECO:0000269\|PubMed:15753205, ECO:0000269\|PubMed:20044979, ECO:0000269\|PubMed:9603476}.
Subcellular Location	Cell membrane {ECO:0000269\|PubMed:15728234, ECO:0000269\|PubMed:16863918}; Multi-pass membrane protein {ECO:0000269\|PubMed:15728234, ECO:0000269\|PubMed:16863918}.
Tissue Specificity	Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes. {ECO:0000269\|PubMed:14530373, ECO:0000269\|PubMed:15728234, ECO:0000269\|PubMed:15753205, ECO:0000269\|PubMed:18242188, ECO:0000269\|PubMed:20044979, ECO:0000269\|PubMed:8976386}.

ChemR23 (C-7) - sc-374570 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

ChemR23 (C-7): sc-374570. Western blot analysis of ChemR23 expression in JAR whole cell lysate.

ChemR23 (H-160) - sc-66829 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

ChemR23 (BZ332) - sc-33726 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rat
Clonality	Monoclonal

ChemR23 (BZ332) PE: sc-33726 PE. FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal rat IgG<sub>2a</sub>: sc-2872.

ChemR23 (C-14) - sc-32651 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

ChemR23 (C-14): sc-32651. Western blot analysis of ChemR23 expression in JAR whole cell lysate.

Anti-CMKLR1 antibody - ab64881 from Abcam

Prices	$382.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-CMKLR1 antibody (ab64881) at 1/500 dilutionLane 1 : extracts from HepG2 cells (5-30µg total protein).Lane 2 : extracts from HeLa cells (5-30µg total protein).Lane 3 : extracts from 293 cells (5-30µg total protein).Lane 4 : extracts from 293 cells (5-30µg total protein) and 5-10µg of the immunising peptide.

Anti-CMKLR1 antibody - ab199603 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-CMKLR1 antibody (ab199603) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : HUVEC cell lysateLysates/proteins at 35 µg per lane.SecondaryGoat anti-rabbit IgG H&L(HRP) at 1/5000 dilution

Anti-CMKLR1 antibody [1A7] - ab167097 from Abcam

Prices	$376.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	1A7

Immunohistochemical analysis of paraffin-embedded Human placenta tissue labeling CMKLR1 with ab167097 at 1&microg/ml.

Anti-CMKLR1 antibody - C-terminal - ab156597 from Abcam

Prices	$376.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CMKLR1 antibody - C-terminal (ab156597) at 1/100 dilution + HL60 cell lysate at 35 µg

Anti-CMKLR1 antibody - C-terminal - ab188795 from Abcam

Prices	$376.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry analysis of formalin/PFA-fixed paraffin-embedded human brain cortex sections labeling CMKLR1 using ab188795 at 5 µg/ml.

Anti-CMKLR1 antibody - N-terminal - ab150491 from Abcam

Prices	$376.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human thymus tissue labelling CMKLR1 with ab150491 at 7 µg/ml

Anti-CHEMR23 / CMKLR1 Antibody (N-Terminus) - LS-C44896 from LifeSpan Bioscience

Prices	$375.00
Sizes	200 µg
Host	Rat
Clonality	Monoclonal

Anti-CHEMR23 / CMKLR1 Antibody (N-Terminus, FITC) - LS-C44897 from LifeSpan Bioscience

Prices	$350.00
Sizes	100 µg
Host	Rat
Clonality	Monoclonal

Anti-CHEMR23 / CMKLR1 Antibody - LS-C96201 from LifeSpan Bioscience

Prices	$345.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CHEMR23 / CMKLR1 Antibody (C-Terminus) - LS-C29837 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CHEMR23 / CMKLR1 Antibody (N-Terminus) IHC-plus™ - LS-A448 from LifeSpan Bioscience

Prices	$395.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CMKLR1 antibody LS-A448 IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CHEMR23 / CMKLR1 Antibody (clone BZ332) - LS-C149715 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µg
Host	Rat
Clonality	Monoclonal
Clone	BZ332

Anti-CHEMR23 / CMKLR1 Antibody (aa305-333, APC) - LS-C255114 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CHEMR23 / CMKLR1 Antibody (aa305-333, AP) - LS-C255113 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CHEMR23 / CMKLR1 Antibody (N-Terminus) IHC-plus™ - LS-A447 from LifeSpan Bioscience

Prices	$395.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CMKLR1 antibody LS-A447 IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CHEMR23 / CMKLR1 Antibody (aa305-333, Biotin) - LS-C255115 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CHEMR23 / CMKLR1 Antibody (aa305-333, Azide-free, HRP) - LS-C255117 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CHEMR23 / CMKLR1 Antibody (aa305-333, FITC) - LS-C255116 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CHEMR23 / CMKLR1 Antibody (aa305-333, PE) - LS-C255119 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CHEMR23 / CMKLR1 Antibody (aa305-333) - LS-C320467 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CHEMR23 / CMKLR1 Antibody (aa221-270) - LS-C119452 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of extracts from HeLa/HUVEC cells, using CMKLR1 Antibody. The lane on the right is treated with the synthesized peptide.

Search more