| Gene Symbol |
CMKLR1
|
| Entrez Gene |
1240
|
| Alt Symbol |
CHEMERINR, ChemR23, DEZ, RVER1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chemerin chemokine-like receptor 1
|
| Other Description |
G-protein coupled receptor ChemR23|G-protein coupled receptor DEZ|chemerin receptor|chemokine receptor-like 1|chemokine-like receptor 1|orphan G-protein coupled receptor, Dez|resolvin E1 receptor
|
| Swissprots |
Q99788 A8K6Y5 Q5U0H0 Q3KP37 O75748 Q99789
|
| Accessions |
AAQ62778 BAC06089 CAA75112 EAW97810 EAW97811 Q99788 AB112777 BAF34667 AK126405 AK291800 BAF84489 AY497547 AAR90850 BC106927 AAI06928 BC106928 AAI06929 BP328503 BT019556 AAV38363 BT019557 AAV38364 DA466082 DA939526 U79526 AAC51258 U79527 AAC51259 NM_001142343 NP_001135815 NM_001142344 NP_001135816 NM_001142345 NP_001135817 NM_004072 NP_004063
|
| Function |
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). {ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:15753205, ECO:0000269|PubMed:20044979, ECO:0000269|PubMed:9603476}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:16863918}; Multi-pass membrane protein {ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:16863918}.
|
| Tissue Specificity |
Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes. {ECO:0000269|PubMed:14530373, ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:15753205, ECO:0000269|PubMed:18242188, ECO:0000269|PubMed:20044979, ECO:0000269|PubMed:8976386}.
|
