CMKLR1

Gene Symbol	CMKLR1
Entrez Gene	1240
Alt Symbol	CHEMERINR, ChemR23, DEZ, RVER1
Species	Human
Gene Type	protein-coding
Description	chemerin chemokine-like receptor 1
Other Description	G-protein coupled receptor ChemR23|G-protein coupled receptor DEZ|chemerin receptor|chemokine receptor-like 1|chemokine-like receptor 1|orphan G-protein coupled receptor, Dez|resolvin E1 receptor
Swissprots	Q99788 A8K6Y5 Q5U0H0 Q3KP37 O75748 Q99789
Accessions	AAQ62778 BAC06089 CAA75112 EAW97810 EAW97811 Q99788 AB112777 BAF34667 AK126405 AK291800 BAF84489 AY497547 AAR90850 BC106927 AAI06928 BC106928 AAI06929 BP328503 BT019556 AAV38363 BT019557 AAV38364 DA466082 DA939526 U79526 AAC51258 U79527 AAC51259 NM_001142343 NP_001135815 NM_001142344 NP_001135816 NM_001142345 NP_001135817 NM_004072 NP_004063
Function	Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). {ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:15753205, ECO:0000269|PubMed:20044979, ECO:0000269|PubMed:9603476}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:16863918}; Multi-pass membrane protein {ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:16863918}.
Tissue Specificity	Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes. {ECO:0000269|PubMed:14530373, ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:15753205, ECO:0000269|PubMed:18242188, ECO:0000269|PubMed:20044979, ECO:0000269|PubMed:8976386}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CMKLR1 full length protein - ab152289 from Abcam Category Protein Source Wheat germ Species Human

CHEMR23 / CMKLR1 Antibody Blocking Peptide - LS-E10750 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHEMR23 / CMKLR1 Antibody Blocking Peptide - LS-E28967 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CHEMR23 / CMKLR1 Antibody Blocking Peptide - LS-E28968 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CHEMR23 / CMKLR1 Antibody Blocking Peptide - LS-E28972 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human ChemR23/CMKLR1 Protein - H00001240-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

CMKLR1 peptide - orb217109 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

CMKLR1 Blocking Peptide - 33R-4461 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CMKLR1 Blocking Peptide - abx062440 from Abbexa Category Peptide Species Human, Mouse, Rat, Pig

Chemokine receptor-like 1 - H00001240-G01 from Acris Antibodies Category Protein Prices $440.00 Sizes 2 µg Species Human

Chemokine receptor-like 1 - H00001240-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

ChemiSCREEN™ Membrane Preparation Recombinant Human ChemR23 Chemoattractant Receptor - HTS071M from EMD Millipore Prices $599.00 Sizes 200 units Species Human

CMKLR1 Blocking Peptide - CBP1246 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Pig

ChemR23 (R249) Peptide - BS2199P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human ChemR23/CMKLR1 Protein - H00001240-G01 from Novus Biologicals Category Protein Prices $415.00 Sizes 2 µg Source Wheat Germ Species Human

ChemR23/CMKLR1 Recombinant Protein Antigen - NBP2-13847PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CMKLR1-Blocking-Peptide-C-term - BP20213b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CMKLR1 Peptide, Human - M34GP03338H from Creative Peptides Category Peptide Source Synthetic. Species Human

Chemerin, Recombinant Protein - MBS637066 from MyBioSource Category Protein Prices $420.00, $840.00 Sizes 25 µg, 100 µg

Chemokine-like receptor 1 (CMKLR1), Recombinant Protein - MBS7011776 from MyBioSource Category Protein Prices $1,180.00, $2,165.00, $3,375.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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