| Gene Symbol |
MEIOB
|
| Entrez Gene |
254528
|
| Alt Symbol |
C16orf73, gs129
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
meiosis specific with OB domains
|
| Other Description |
meiosis-specific with OB domain-containing protein
|
| Swissprots |
Q8N635 C9J0S1 Q96RY0 B1AK39
|
| Accessions |
AAK61296 CAM28376 EAW85604 EAW85605 EAW85606 EAW85607 Q8N635 BC029829 AAH29829 CD300613 DB461414 DQ891299 ABM82225 DQ894483 ABM85409 NM_001163560 NP_001157032 NM_152764 NP_689977
|
| Function |
Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Co-localizes with the RPA complex on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on SPATA22 (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
In fetal gonads, specifically expressed in the ovary starting at the 14th weeks post fertilization. {ECO:0000269|PubMed:24068956}.
|