CREB3

Gene Symbol	CREB3
Entrez Gene	10488
Alt Symbol	LUMAN, LZIP, sLZIP
Species	Human
Gene Type	protein-coding
Description	cAMP responsive element binding protein 3
Other Description	CREB-3\|basic leucine zipper protein\|cAMP-responsive element-binding protein 3\|cyclic AMP response element (CRE)-binding protein/activating transcription factor 1\|cyclic AMP-responsive element-binding protein 3\|leucin zipper proitein\|leucine zipper protein\|small leucine zipper protein\|transcription factor LZIP-alpha
Swissprots	Q9H2W3 Q9UE77 Q5TCV1 O14671 Q96GK8 O43889 D0PTW6 O14919
Accessions	AAD09210 AAG43527 EAW58350 EAW58351 O43889 AF009368 AAB69652 AF029674 AAB84166 AF211848 AAG43528 AK299781 BAG61663 AK313635 BAG36394 BC009402 AAH09402 BC010158 AAH10158 BG701230 BQ014045 EU446868 ABZ92397 FJ263669 ACN32251 U88528 AAC04325 NM_006368 NP_006359
Function	Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcripti
Subcellular Location	Processed cyclic AMP-responsive element- binding protein 3: Nucleus. Note=Upon RIP activation the transcriptional active processed cyclic AMP-responsive element- binding protein 3 form translocates into the nucleus. Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes with CREBRF in nuclear foci. Colocalizes with CREBZF in promyelocytic leukemia protein nuclear bodies (PML-NB).
Tissue Specificity	Expressed in dendritic cells (DC). Weakly expressed in monocytes (at protein level). Ubiquitous. {ECO:0000269\|PubMed:10675342, ECO:0000269\|PubMed:19779205, ECO:0000269\|PubMed:20546900, ECO:0000269\|PubMed:9271389, ECO:0000269\|PubMed:9389645}.
Top Pathways	cGMP-PKG signaling pathway, Huntington's disease, Glucagon signaling pathway, Prostate cancer, cAMP signaling pathway

LZIP (N-20) - sc-25071 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

LZIP (N-20): sc-25071. Western blot analysis of LZIP expression in non-transfected: sc-117752 (A) and mouse LZIP transfected: sc-125570 (B) 293T whole cell lysates.

LZIP (C-20) - sc-25073 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

LZIP (Q-61) - sc-100994 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	50 µg/0.5 ml
Host	Mouse
Clonality	Monoclonal

LZIP (Q-61): sc-100994. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human testis tissue showing nuclear and cytoplasmic localization.

Anti-CREB3 antibody - ab78182 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-CREB3 antibody (ab78182) at 1 µg/mlLane 1 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLane 2 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CREB3 antibody - ab191541 from Abcam

Prices	$376.00
Sizes	50 µg
Host	Goat
Clonality	Polyclonal

Anti-CREB3 antibody (ab191541) at 0.3 µg/ml + HepG2 lysate at 35 µgdeveloped using the ECL technique

Anti-CREB3 antibody - ab56650 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

CREB3 antibody (ab56650) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human testis.

Anti-CREB3 antibody - ab151287 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of paraffin-embedded Human A549 xenograft tissue labeling CREB3 with ab151287 at 1/100 dilution.

Anti-CREB3 antibody - ab178530 from Abcam

Prices	$376.00
Sizes	200 µl
Host	Goat
Clonality	Polyclonal

Anti-CREB3 antibody (ab178530) at 0.3 µg/ml + HepG2 cell lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-CREB3 antibody [EPR14215(B)] - ab180119 from Abcam

Prices	$384.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR14215(B)

Anti-CREB3 antibody [EPR14215(B)] (ab180119) at 1/2000 dilution + HeLa cell lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-CREB3 / LZIP Antibody (aa76-87) IHC-plus™ - LS-B10571 from LifeSpan Bioscience

Host	Goat
Clonality	Polyclonal

Anti-CREB3 / LZIP antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10571 concentration 5 ug/ml.

Anti-CREB3 / LZIP Antibody (aa273-372, Azide-free) - LS-C327120 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal

Anti-CREB3 / LZIP Antibody (clone 2206C2a) - LS-C342692 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	2206C2a

Left : Western blot analysis of immunized recombinant protein, using anti-CREB3 monoclonal antibody. Right : CBB staining of immunized recombinant protein.

Anti-CREB3 / LZIP Antibody - LS-C334801 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts of various cell lines, using CREB3 antibody.

Anti-CREB3 / LZIP Antibody (clone 3H5) - LS-C133649 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	3H5

Immunoperoxidase of monoclonal antibody to CREB3 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml]

Anti-CREB3 / LZIP Antibody (aa66-94) IHC-plus™ - LS-B10031 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CREB3 / LZIP antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CREB3 / LZIP Antibody - LS-C79914 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal

Anti-CREB3 / LZIP Antibody (clone 2206C2a) - LS-C184659 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	2206C2a

Anti-CREB3 / LZIP Antibody (aa247-296) - LS-C30104 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CREB3 / LZIP Antibody (aa66-94, AP) - LS-C255405 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CREB3 / LZIP Antibody (aa66-94, APC) - LS-C255406 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CREB3 / LZIP Antibody (aa66-94, FITC) - LS-C255407 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CREB3 / LZIP Antibody (aa66-94, Biotin) - LS-C255408 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CREB3 / LZIP Antibody (aa66-94, Azide-free, HRP) - LS-C255409 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CREB3 / LZIP Antibody (aa180-229) - LS-C109713 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

CREB3 antibody LS-C109713 Western blot of Fetal Muscle lysate.

Anti-CREB3 / LZIP Antibody (aa66-94, PE) - LS-C255410 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

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