CREB3

Gene Symbol CREB3
Entrez Gene 10488
Alt Symbol LUMAN, LZIP, sLZIP
Species Human
Gene Type protein-coding
Description cAMP responsive element binding protein 3
Other Description CREB-3|basic leucine zipper protein|cAMP-responsive element-binding protein 3|cyclic AMP response element (CRE)-binding protein/activating transcription factor 1|cyclic AMP-responsive element-binding protein 3|leucin zipper proitein|leucine zipper protein|small leucine zipper protein|transcription factor LZIP-alpha
Swissprots Q9H2W3 Q9UE77 Q5TCV1 O14671 Q96GK8 O43889 D0PTW6 O14919
Accessions AAD09210 AAG43527 EAW58350 EAW58351 O43889 AF009368 AAB69652 AF029674 AAB84166 AF211848 AAG43528 AK299781 BAG61663 AK313635 BAG36394 BC009402 AAH09402 BC010158 AAH10158 BG701230 BQ014045 EU446868 ABZ92397 FJ263669 ACN32251 U88528 AAC04325 NM_006368 NP_006359
Function Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcripti
Subcellular Location Processed cyclic AMP-responsive element- binding protein 3: Nucleus. Note=Upon RIP activation the transcriptional active processed cyclic AMP-responsive element- binding protein 3 form translocates into the nucleus. Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes with CREBRF in nuclear foci. Colocalizes with CREBZF in promyelocytic leukemia protein nuclear bodies (PML-NB).
Tissue Specificity Expressed in dendritic cells (DC). Weakly expressed in monocytes (at protein level). Ubiquitous. {ECO:0000269|PubMed:10675342, ECO:0000269|PubMed:19779205, ECO:0000269|PubMed:20546900, ECO:0000269|PubMed:9271389, ECO:0000269|PubMed:9389645}.
Top Pathways cGMP-PKG signaling pathway, Huntington's disease, Glucagon signaling pathway, Prostate cancer, cAMP signaling pathway

LZIP CRISPR/Cas9 KO Plasmid (h) - sc-406526 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LZIP HDR Plasmid (h) - sc-406526-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LZIP Double Nickase Plasmid (h) - sc-406526-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LZIP Double Nickase Plasmid (h2) - sc-406526-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LZIP CRISPR Activation Plasmid (h) - sc-406526-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LZIP CRISPR Activation Plasmid (h2) - sc-406526-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LZIP Lentiviral Activation Particles (h) - sc-406526-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LZIP Lentiviral Activation Particles (h2) - sc-406526-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LZIP siRNA (h) - sc-37702 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LZIP shRNA Plasmid (h) - sc-37702-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LZIP shRNA (h) Lentiviral Particles - sc-37702-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU097331 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6552 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6552 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CREB3 siRNA (Human) - CRH7125 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CREB3 RNAi - H00010488-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CREB3 - MBS8231265 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

LZIP CRISPR/Cas9 KO Plasmid (h2) - sc-406526-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LZIP HDR Plasmid (h2) - sc-406526-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human CREB3 (NM_006368.4) - SHH269297 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CREB3(NM_006368.4) - SHG197947 from Creative biogene

Category siRNA
Species Reactivities Human

Human CREB3 siRNA - orb267627 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CREB3 shRNA Plasmid (Human) - CHH7125 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CREB3 miRNA 3'UTR clone - MiUTR1H-02410 from Creative biogene

Species Reactivities Human
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