CREB3

Gene Symbol	CREB3
Entrez Gene	10488
Alt Symbol	LUMAN, LZIP, sLZIP
Species	Human
Gene Type	protein-coding
Description	cAMP responsive element binding protein 3
Other Description	CREB-3|basic leucine zipper protein|cAMP-responsive element-binding protein 3|cyclic AMP response element (CRE)-binding protein/activating transcription factor 1|cyclic AMP-responsive element-binding protein 3|leucin zipper proitein|leucine zipper protein|small leucine zipper protein|transcription factor LZIP-alpha
Swissprots	Q9H2W3 Q9UE77 Q5TCV1 O14671 Q96GK8 O43889 D0PTW6 O14919
Accessions	AAD09210 AAG43527 EAW58350 EAW58351 O43889 AF009368 AAB69652 AF029674 AAB84166 AF211848 AAG43528 AK299781 BAG61663 AK313635 BAG36394 BC009402 AAH09402 BC010158 AAH10158 BG701230 BQ014045 EU446868 ABZ92397 FJ263669 ACN32251 U88528 AAC04325 NM_006368 NP_006359
Function	Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcripti
Subcellular Location	Processed cyclic AMP-responsive element- binding protein 3: Nucleus. Note=Upon RIP activation the transcriptional active processed cyclic AMP-responsive element- binding protein 3 form translocates into the nucleus. Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes with CREBRF in nuclear foci. Colocalizes with CREBZF in promyelocytic leukemia protein nuclear bodies (PML-NB).
Tissue Specificity	Expressed in dendritic cells (DC). Weakly expressed in monocytes (at protein level). Ubiquitous. {ECO:0000269|PubMed:10675342, ECO:0000269|PubMed:19779205, ECO:0000269|PubMed:20546900, ECO:0000269|PubMed:9271389, ECO:0000269|PubMed:9389645}.
Top Pathways	cGMP-PKG signaling pathway, Huntington's disease, Glucagon signaling pathway, Prostate cancer, cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CREB3 Peptide - AC21-2985-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CREB3 - H00010488-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CREB3 - H00010488-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CREB3 fusion protein - ag1823 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Cyclic AMP-responsive element-binding protein 3(CREB3) - CSB-YP005948HU CSB-EP005948HU CSB-BP005948HU CSB-MP005948HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CREB3, Peptide - MBS428586 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

CREB3-Blocking-Peptide-N-term - BP20041a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CREB3-Blocking-Peptide-C-term - BP21435b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CREB3 Antibody - SH-A11278 from Novatein Biosciences Prices $315.00 Sizes 100 µl Species Human

CREB3 Blocking Peptide - CBP7503 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Bovine

Cyclic AMP-responsive element-binding protein 3, Recombinant Protein - MBS7042577 from MyBioSource Category Protein Prices $1,200.00, $2,185.00, $3,395.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

Cyclic AMP-responsive element-binding protein 3 (CREB3), Recombinant Protein - MBS1236139 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

CREB3 peptide - orb382408 from Biorbyt Category Peptide Species Bovine, Human, Mouse

Search more