CCND2

Gene Symbol CCND2
Entrez Gene 894
Alt Symbol KIAK0002, MPPH3
Species Human
Gene Type protein-coding
Description cyclin D2
Other Description G1/S-specific cyclin-D2
Swissprots A8K531 P30279 Q13955 Q5U035
Accessions AAA51928 AAM54041 EAW88851 P30279 AI055922 AK223577 BAD97297 AK291146 BAF83835 BC010958 AAH10958 BC014357 BC089384 AAH89384 BT019847 AAV38650 BX476896 BX647508 D13639 BAA02802 DQ892845 ABM83771 DQ896091 ABM87090 M90813 AAA51926 X68452 CAA48493 XM_005253813 XP_005253870 NM_001759 NP_001750
Function Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000269|PubMed:18827403}. Cytoplasm {ECO:0000269|PubMed:18827403}. Membrane {ECO:0000269|PubMed:18827403}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
Top Pathways PI3K-Akt signaling pathway, Cell cycle, p53 signaling pathway, MicroRNAs in cancer, Focal adhesion

Cyclin D2 (D52F9) Rabbit mAb - 3741 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D52F9
Western blot analysis of extracts from various cell lines using Cyclin D2 (D52F9) Rabbit mAb.

Cyclin D2 Antibody - 2924 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Raji cells, using Cyclin D2 Antibody.

cyclin D2 (C-17) - sc-181 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
cyclin D2 (C-17): sc-181. Western blot analysis of cyclin D2 expression in MM142 nuclear extract.

cyclin D2 (34B1-3) - sc-452 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
cyclin D2 (34B1-3): sc-452. Western blot analysis of cyclin D2 expression in MM-142 nuclear extract.

cyclin D2 (H-289) - sc-754 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
cyclin D2 (H-289): sc-754. Western blot analysis of cyclin D2 expression in MM-142 nuclear extract.

cyclin D2 (DCS-5) - sc-53637 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cyclin D2 (DCS-5): sc-53637. Western blot analysis of cyclin D2 expression in MM-142 nuclear extract under reducing (A) and non-reducing (B) conditions.

cyclin D2 (DCS-3) - sc-56305 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cyclin D2 (DCS-3): sc-56305. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in tubules.

cyclin D2 (SPM388) - sc-65551 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cyclin D2 (SPM388): sc-65551. Western blot analysis of cyclin D2 expression in MM-142 nuclear extract.

Anti-Cyclin D2 antibody - ab79482 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cyclin D2 antibody (ab79482) at 1/1000 dilutionLane 1 : extracts from 293 cellsLane 2 : extracts from 293 cells with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-Cyclin D2 antibody - ab81359 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cyclin D2 antibody (ab81359) at 1 µg/mlLane 1 : Tissue lysates prepared from Rat testicle tissue.Lane 2 : Tissue lysates prepared from Rat ovary tissue.Lane 3 : Tissue lysates prepared from Rat placental tissue.Lane 4 : Whole cell lysates prepared from MCF7 cells.Lane 5 : Whole cell lysates prepared from MM231 cells.Lane 6 : Whole cell lysates prepared from Hela cells.Lane 7 : Whole cell lysates prepared from HT1080 cells.Lane 8 : Whole cell lysates prepared from colo320 cells.Lysates/proteins at 50 µg per lane.SecondaryHRP-conjugated Goat anti-rabbit IgG at 1/3000 dilution

Anti-Cyclin D2 antibody - ab89595 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Cyclin D2 antibody (ab89595) at 1 µg/ml + Human placenta tissue lysate at 50 µg

Anti-Cyclin D2 antibody [CY-D2] - ab130006 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone CY-D2

Anti-Cyclin D2 antibody [DCS-3.1] - ab3085 from Abcam

Prices $394.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone DCS-3.1
ab3085 staining Cyclin D2 in murine embryonic fibroblast cells by Immunocytochemistry/ Immunofluorescence. The cells were paraformaldehyde fixed at room temperature for 5 minutes, permeabilised in 0.1% Triton X-100 for 10 minutes and then blocked using 10% house serum, 5% BSA for 1 hour at room temperature. Samples were then incubated with primary antibody at 2µg/ml for 16 hours at 4°C. The secondary antibody used was a goat anti-mouse IgG conjugated to Alexa Fluor® 546 (red) used at a 1/500 dilution. DAPI was used to stain the cell nuclei (blue).See Abreview

Anti-Cyclin D2 antibody [DCS-3.1] - ab140323 from Abcam

Prices $373.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone DCS-3.1

Anti-Cyclin D2 antibody [DCS-3.1 + DCS-5.2] - ab3087 from Abcam

Prices $385.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone DCS-3.1 + DCS-5.2
Anti-Cyclin D2 antibody [DCS-3.1 + DCS-5.2] (ab3087) at 1 µg/ml + Placenta (Human) Tissue Lysate - adult normal tissue (ab29745) at 10 µgSecondaryGoat polyclonal to Mouse IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Cyclin D2 antibody - N-terminal - ab172911 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Cyclin D2 antibody - N-terminal (ab172911) at 1/100 dilution + CEM cell line lysate at 35 µg

Anti-CCND2 / Cyclin D2 Antibody (clone DCS3.1) - LS-C26467 from LifeSpan Bioscience

Prices $330.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone DCS3.1

Anti-CCND2 / Cyclin D2 Antibody (clone DCS-3.1, Azide-free) - LS-C87946 from LifeSpan Bioscience

Prices $590.00, $860.00
Sizes 100 µg, 200 µg
Host Mouse
Clonality Monoclonal
Clone DCS-3.1

Anti-CCND2 / Cyclin D2 Antibody (clone DCS-3.1 + DCS-5.2) - LS-C87952 from LifeSpan Bioscience

Prices $280.00, $530.00, $805.00
Sizes 20 µg, 500 µl, 200 µg
Host Mouse
Clonality Monoclonal

Anti-CCND2 / Cyclin D2 Antibody (clone DCS-3.1 + DCS-5.2, Azide-free) - LS-C87953 from LifeSpan Bioscience

Prices $590.00, $860.00
Sizes 100 µg, 200 µg
Host Mouse
Clonality Monoclonal

Anti-CCND2 / Cyclin D2 Antibody (clone DCS-3.1) - LS-C87945 from LifeSpan Bioscience

Prices $280.00, $530.00, $810.00
Sizes 100 µl, 500 µl, 1 ml
Host Mouse
Clonality Monoclonal
Clone DCS-3.1

Anti-CCND2 / Cyclin D2 Antibody - LS-C128456 from LifeSpan Bioscience

Prices $405.00
Sizes 5 ml
Host Mouse
Clonality Monoclonal

Anti-CCND2 / Cyclin D2 Antibody - LS-C128457 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CCND2 / Cyclin D2 Antibody - LS-C128458 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CCND2 / Cyclin D2 Antibody (aa46-60) - LS-C128459 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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