| Gene Symbol | GDF9 |
|---|---|
| Entrez Gene | 2661 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | growth differentiation factor 9 |
| Other Description | GDF-9|growth/differentiation factor 9 |
| Swissprots | Q4VAW5 O60383 |
| Accessions | AAC08450 EAW62309 O60383 AA604716 AK301962 BAG63375 AK315973 BAH14344 BC096228 AAH96228 BC096229 AAH96229 BC096230 AAH96230 BC096231 AAH96231 BX117145 CA488820 DB040027 DB320693 HY015857 HY042819 HY045713 HY211060 XM_005271957 XP_005272014 XM_006714585 XP_006714648 XM_011543308 XP_011541610 XM_011543309 XP_011541611 XM_011543310 XP_011541612 XM_011543311 XP_011541613 NM_001288824 NP_001275753 NM_001288825 NP_001275754 NM_001288826 NP_001275755 NM_001288827 NP_001275756 NM_001288828 NP_001275757 NM_005260 NP_005251 |
| Function | Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. {ECO:0000269|PubMed:12050262, ECO:0000269|PubMed:19366876, ECO:0000269|PubMed:20660033, ECO:0000269|PubMed:21632818, ECO:0000269|PubMed:21829661}. |
| Subcellular Location | Secreted {ECO:0000250}. |
| Tissue Specificity | Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level). {ECO:0000269|PubMed:10443672, ECO:0000269|PubMed:12050262}. |
| Top Pathways | Ovarian steroidogenesis |