GDF9

Gene Symbol GDF9
Entrez Gene 2661
Alt Symbol -
Species Human
Gene Type protein-coding
Description growth differentiation factor 9
Other Description GDF-9|growth/differentiation factor 9
Swissprots Q4VAW5 O60383
Accessions AAC08450 EAW62309 O60383 AA604716 AK301962 BAG63375 AK315973 BAH14344 BC096228 AAH96228 BC096229 AAH96229 BC096230 AAH96230 BC096231 AAH96231 BX117145 CA488820 DB040027 DB320693 HY015857 HY042819 HY045713 HY211060 XM_005271957 XP_005272014 XM_006714585 XP_006714648 XM_011543308 XP_011541610 XM_011543309 XP_011541611 XM_011543310 XP_011541612 XM_011543311 XP_011541613 NM_001288824 NP_001275753 NM_001288825 NP_001275754 NM_001288826 NP_001275755 NM_001288827 NP_001275756 NM_001288828 NP_001275757 NM_005260 NP_005251
Function Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. {ECO:0000269|PubMed:12050262, ECO:0000269|PubMed:19366876, ECO:0000269|PubMed:20660033, ECO:0000269|PubMed:21632818, ECO:0000269|PubMed:21829661}.
Subcellular Location Secreted {ECO:0000250}.
Tissue Specificity Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level). {ECO:0000269|PubMed:10443672, ECO:0000269|PubMed:12050262}.
Top Pathways Ovarian steroidogenesis

GDF9-Over-expression-Lysate - LY10732a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag GDF9 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GDF9 gene

GDF9 293T Cell Transient Overexpression Lysate(Denatured) - H00002661-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

GDF9 overexpression lysate - LY417406 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

GDF9 293 Cell Lysate - 408141 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg

GDF-9 Overexpression Lysate (Denatured) - H00002661-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

GDF9 Over-expression Lysate Product - GWB-BC0718 from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

GDF-9 Overexpression Lysate (Native) - NBP2-10477 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: GDF 9 Overexpression Lysate (Adult Normal) [NBP2-10477] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GDF 9.

GDF-9 Overexpression Lysate (Denatured) - H00002661-T02 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

Panoply™ Human GDF9 Knockdown Stable Cell Line - CSC-DC006193 from Creative biogene

Category Cell Line
Species Human
Search more