| Gene Symbol |
RTCB
|
| Entrez Gene |
51493
|
| Alt Symbol |
C22orf28, DJ149A16.6, FAAP, HSPC117
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RNA 2',3'-cyclic phosphate and 5'-OH ligase
|
| Other Description |
ankyrin repeat domain 54|focal adhesion-associated protein|tRNA-splicing ligase RtcB homolog
|
| Swissprots |
Q9BWL4 Q9P037 B2R6A8 Q9P0J3 Q9Y3I0 Q9NTH1 Q6IAI0
|
| Accessions |
EAW60021 Q9Y3I0 AF155658 AAF67477 AF161466 AAF29081 AK297826 BAG60162 AK297908 BAG60227 AK301945 BAG63363 AK312503 BAG35405 AL050255 CAB43357 AL137272 CAB70670 BC000151 AAH00151 BC002970 AAH02970 BC010308 AAH10308 BC016707 AAH16707 BU615556 CR456450 CAG30336 CR457175 CAG33456 DC396330 DQ890931 ABM81857 DQ894092 ABM85018 NM_014306 NP_055121
|
| Function |
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'- phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. {ECO:0000269|PubMed:21311021, ECO:0000269|PubMed:24870230}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:24608264}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03144, ECO:0000269|PubMed:24608264}. Note=Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low. {ECO:0000269|PubMed:24608264}.
|
![Western Blot: C22orf28 Overexpression Lysate (Adult Normal) [NBL1-08394] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for C22orf28.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9368_C22orf28%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08394-img0002.jpg)