| Gene Symbol |
HACD4
|
| Entrez Gene |
401494
|
| Alt Symbol |
PTPLAD2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
3-hydroxyacyl-CoA dehydratase 4
|
| Other Description |
protein tyrosine phosphatase-like A domain containing 2|protein tyrosine phosphatase-like protein PTPLAD2|protein-tyrosine phosphatase-like A domain-containing protein 2|very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4|very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 4
|
| Swissprots |
Q7Z385 Q5VWC8
|
| Accessions |
EAW58626 Q5VWC8 BC114215 AAI14216 BX538052 CAD97990 BX648779 XM_005251459 XP_005251516 XM_011517873 XP_011516175 XM_011517874 XP_011516176 XM_011517875 XP_011516177 XM_011517876 XP_011516178 XR_929251 NM_001010915 NP_001010915
|
| Function |
Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:18554506}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:18554506}; Multi-pass membrane protein {ECO:0000269|PubMed:18554506}.
|
| Tissue Specificity |
Highly expressed in leukocytes, and low expression in heart, spleen, kidney, and placenta. {ECO:0000269|PubMed:18554506}.
|
| Top Pathways |
Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism
|