HACD4

Gene Symbol HACD4
Entrez Gene 401494
Alt Symbol PTPLAD2
Species Human
Gene Type protein-coding
Description 3-hydroxyacyl-CoA dehydratase 4
Other Description protein tyrosine phosphatase-like A domain containing 2|protein tyrosine phosphatase-like protein PTPLAD2|protein-tyrosine phosphatase-like A domain-containing protein 2|very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4|very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 4
Swissprots Q7Z385 Q5VWC8
Accessions EAW58626 Q5VWC8 BC114215 AAI14216 BX538052 CAD97990 BX648779 XM_005251459 XP_005251516 XM_011517873 XP_011516175 XM_011517874 XP_011516176 XM_011517875 XP_011516177 XM_011517876 XP_011516178 XR_929251 NM_001010915 NP_001010915
Function Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:18554506}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:18554506}; Multi-pass membrane protein {ECO:0000269|PubMed:18554506}.
Tissue Specificity Highly expressed in leukocytes, and low expression in heart, spleen, kidney, and placenta. {ECO:0000269|PubMed:18554506}.
Top Pathways Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism

PTPLAD2 (C-13) - sc-139423 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

PTPLAD2 (N-12) - sc-139420 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-HACD4 / PTPLAD2 Antibody (aa72-121) - LS-C102119 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PTPLAD2 antibody LS-C102119 Western blot of 293T cell lysate.

PTPLAD2 Antibody - NBP2-31725 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PTPLAD2 Antibody [NBP2-31725] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10. Lane 2: Lung

PTPLAD2 Antibody - NBP1-59414 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PTPLAD2 Antibody [NBP1-59414] - 293T cells lysate, concentration 0.2-1 ug/ml.

Anti-PTPLAD2 antibody produced in rabbit - HPA058666 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PTPLAD2: <B>Cat. No. HPA058666</B>: Immunohistochemical staining of Human salivary gland shows moderate membranous and cytoplasmic positivity in glandular cells.

PTPLAD2 antibody - middle region (ARP44598_P050) - ARP44598_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PTPLAD2 antibody - 70R-6315 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

PTPLAD2 Antibody - 25-983 from ProSci

Prices $315.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Antibody used in WB on Human 293T at 0.2-1 ug/ml.

PTPLAD2 Antibody - GWB-MP887E from Genway Biotech

Prices $368.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PTPLAD2 (aa 72-121) polyclonal antibody - DPABH-18295 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

PTPLAD2 antibody, Internal - GTX46677 from GeneTex

Prices $299.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Anti-PTPLAD2 antibody, Internal used in Western blot. GTX46677

PTPLAD2-antibody-middle-region-AI12455 - AI12455 from Abgent, a WuXi AppTec company

Prices $293.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
WB Suggested Anti-PTPLAD2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: 293T cell lysate

PTPLAD2, Polyclonal Antibody - MBS5301844 from MyBioSource

Prices $455.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PTPLAD2 antibody produced in rabbit - SAB2101909 from Sigma-Aldrich

Prices $358.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PTPLAD2: <B>Cat. No.SAB2101909</B>: PTPLAD2 in 293T cell lysate with PTPLAD2 antibody at 1.0 μg/mL.

PTPLAD2 antibody - TA336126 from Acris Antibodies

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
WB Suggested Anti-PTPLAD2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: 293T cell lysate

Anti-HACD4 / PTPLAD2 Antibody (aa72-121, Biotin) - LS-C446776 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
PTPLAD2 antibody LS-C102119 Western blot of 293T cell lysate. This image was taken for the base form of this product. Alternate forms, such as conjugated, azide-free, or ready-to-use, have not been tested.

Anti-HACD4 / PTPLAD2 Antibody (aa72-121, FITC) - LS-C446777 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
PTPLAD2 antibody LS-C102119 Western blot of 293T cell lysate. This image was taken for the base form of this product. Alternate forms, such as conjugated, azide-free, or ready-to-use, have not been tested.

Anti-HACD4 / PTPLAD2 Antibody (aa72-121, HRP) - LS-C446778 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
PTPLAD2 antibody LS-C102119 Western blot of 293T cell lysate. This image was taken for the base form of this product. Alternate forms, such as conjugated, azide-free, or ready-to-use, have not been tested.

PTPLAD2 antibody - middle region : Biotin (ARP44598_P050-Biotin) - ARP44598_P050-Biotin from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal

PTPLAD2 antibody - middle region : FITC (ARP44598_P050-FITC) - ARP44598_P050-FITC from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal

PTPLAD2 antibody - middle region : HRP (ARP44598_P050-HRP) - ARP44598_P050-HRP from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal
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