| Gene Symbol | HACD4 |
|---|---|
| Entrez Gene | 401494 |
| Alt Symbol | PTPLAD2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | 3-hydroxyacyl-CoA dehydratase 4 |
| Other Description | protein tyrosine phosphatase-like A domain containing 2|protein tyrosine phosphatase-like protein PTPLAD2|protein-tyrosine phosphatase-like A domain-containing protein 2|very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4|very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 4 |
| Swissprots | Q7Z385 Q5VWC8 |
| Accessions | EAW58626 Q5VWC8 BC114215 AAI14216 BX538052 CAD97990 BX648779 XM_005251459 XP_005251516 XM_011517873 XP_011516175 XM_011517874 XP_011516176 XM_011517875 XP_011516177 XM_011517876 XP_011516178 XR_929251 NM_001010915 NP_001010915 |
| Function | Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:18554506}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:18554506}; Multi-pass membrane protein {ECO:0000269|PubMed:18554506}. |
| Tissue Specificity | Highly expressed in leukocytes, and low expression in heart, spleen, kidney, and placenta. {ECO:0000269|PubMed:18554506}. |
| Top Pathways | Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism |
PTPLAD2 CRISPR/Cas9 KO Plasmid (h) - sc-417162 from Santa Cruz Biotechnology
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PTPLAD2 HDR Plasmid (h) - sc-417162-HDR from Santa Cruz Biotechnology
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PTPLAD2 Double Nickase Plasmid (h) - sc-417162-NIC from Santa Cruz Biotechnology
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PTPLAD2 Double Nickase Plasmid (h2) - sc-417162-NIC-2 from Santa Cruz Biotechnology
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PTPLAD2 CRISPR Activation Plasmid (h) - sc-417162-ACT from Santa Cruz Biotechnology
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PTPLAD2 CRISPR Activation Plasmid (h2) - sc-417162-ACT-2 from Santa Cruz Biotechnology
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PTPLAD2 Lentiviral Activation Particles (h) - sc-417162-LAC from Santa Cruz Biotechnology
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PTPLAD2 Lentiviral Activation Particles (h2) - sc-417162-LAC-2 from Santa Cruz Biotechnology
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PTPLAD2 siRNA (h) - sc-92656 from Santa Cruz Biotechnology
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PTPLAD2 shRNA Plasmid (h) - sc-92656-SH from Santa Cruz Biotechnology
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PTPLAD2 shRNA (h) Lentiviral Particles - sc-92656-V from Santa Cruz Biotechnology
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MISSION® Human Phosphatase - SIHP0717 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0715 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0716 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17693 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17693 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05859 from Sigma-Aldrich
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PTPLAD2 siRNA (Human) - CRJ8135 from Cohesion Biosciences
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shRNA set against Human Ptplad2 (NM_001010915.3) - SHH386384 from Creative biogene
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Human PTPLAD2 siRNA - orb278636 from Biorbyt
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PTPLAD2 shRNA Plasmid (Human) - CHJ8135 from Cohesion Biosciences
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PTPLAD2 miRNA 3'UTR clone - MiUTR1H-08445 from Creative biogene
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