Gene Symbol | CHERP |
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Entrez Gene | 10523 |
Alt Symbol | DAN16, SCAF6, SRA1 |
Species | Human |
Gene Type | protein-coding |
Description | calcium homeostasis endoplasmic reticulum protein |
Other Description | ERPROT 213-21|ERPROT213-21|SR-related CTD associated factor 6|SR-related CTD-associated factor 6|protein with polyglutamine repeat |
Swissprots | Q8IWX8 Q99492 Q4G0Y5 Q8WU30 O00302 |
Accessions | EAW84549 Q8IWX8 AA782418 AB209730 BAD92967 AF536542 AAN77183 AK296883 BAG59444 AK298408 BAG60636 BC001552 BC021294 AAH21294 BC035039 CN336425 U94836 AAB53327 Y08265 CAA69591 NM_006387 NP_006378 |
Function | Involved in calcium homeostasis, growth and proliferation. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674, ECO:0000269|PubMed:8010949}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674, ECO:0000269|PubMed:8010949}. Endoplasmic reticulum {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674, ECO:0000269|PubMed:8010949}. Note=Distributed throughout the cytoplasm and also localizes to the perinuclear region of both human erythroleukemia (HEL) cells and Jurkat cells. Colocalizes with ITPR1. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674, ECO:0000269|PubMed:8010949}. |
Tissue Specificity | Expressed in brain, placenta, lung, liver, kidney, pancreas, cardiac and skeletal muscle, and in cultured HEL and Dami cells. {ECO:0000269|PubMed:10794731}. |
Top Pathways | Spliceosome |
CHERP CRISPR/Cas9 KO Plasmid (h) - sc-409569 from Santa Cruz Biotechnology
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CHERP HDR Plasmid (h) - sc-409569-HDR from Santa Cruz Biotechnology
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CHERP Double Nickase Plasmid (h) - sc-409569-NIC from Santa Cruz Biotechnology
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CHERP Double Nickase Plasmid (h2) - sc-409569-NIC-2 from Santa Cruz Biotechnology
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CHERP CRISPR Activation Plasmid (h) - sc-409569-ACT from Santa Cruz Biotechnology
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CHERP CRISPR Activation Plasmid (h2) - sc-409569-ACT-2 from Santa Cruz Biotechnology
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CHERP Lentiviral Activation Particles (h) - sc-409569-LAC from Santa Cruz Biotechnology
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CHERP Lentiviral Activation Particles (h2) - sc-409569-LAC-2 from Santa Cruz Biotechnology
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CHERP siRNA (h) - sc-97408 from Santa Cruz Biotechnology
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CHERP shRNA Plasmid (h) - sc-97408-SH from Santa Cruz Biotechnology
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CHERP shRNA (h) Lentiviral Particles - sc-97408-V from Santa Cruz Biotechnology
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CHERP RNAi - H00010523-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN6051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6051 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08759 from Sigma-Aldrich
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CHERP siRNA (Human) - CRH7150 from Cohesion Biosciences
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CHERP - MBS827293 from MyBioSource
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shRNA set against Human CHERP (NM_006387.5) - SHH262973 from Creative biogene
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shRNA set against Human CHERP(NM_006387.5) - SHG174475 from Creative biogene
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Human CHERP siRNA - orb267652 from Biorbyt
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CHERP shRNA Plasmid (Human) - CHH7150 from Cohesion Biosciences
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CHERP miRNA 3'UTR clone - MiUTR1H-02113 from Creative biogene
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