| Gene Symbol |
PFN1
|
| Entrez Gene |
5216
|
| Alt Symbol |
ALS18
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
profilin 1
|
| Other Description |
epididymis tissue protein Li 184a|profilin I|profilin-1
|
| Swissprots |
Q53Y44 P07737
|
| Accessions |
EAW90381 EAW90382 EAW90383 EAW90384 P07737 AA358044 AK312168 BAG35102 AL525538 BC002475 AAH02475 BC006768 AAH06768 BC013439 AAH13439 BC015164 AAH15164 BC057828 AAH57828 BM850671 BT007001 AAP35647 CR407670 CAG28598 D28377 BAA05743 DQ891100 ABM82026 DQ894282 ABM85208 GU727630 ADU87632 J03191 AAA36486 NM_005022 NP_005013
|
| Function |
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. {ECO:0000269|PubMed:18573880}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton.
|
| Tissue Specificity |
Expressed in epididymis (at protein level). {ECO:0000269|PubMed:20736409}.
|
| Top Pathways |
Salmonella infection, Rap1 signaling pathway, Regulation of actin cytoskeleton
|
