PFN1

Gene Symbol	PFN1
Entrez Gene	5216
Alt Symbol	ALS18
Species	Human
Gene Type	protein-coding
Description	profilin 1
Other Description	epididymis tissue protein Li 184a|profilin I|profilin-1
Swissprots	Q53Y44 P07737
Accessions	EAW90381 EAW90382 EAW90383 EAW90384 P07737 AA358044 AK312168 BAG35102 AL525538 BC002475 AAH02475 BC006768 AAH06768 BC013439 AAH13439 BC015164 AAH15164 BC057828 AAH57828 BM850671 BT007001 AAP35647 CR407670 CAG28598 D28377 BAA05743 DQ891100 ABM82026 DQ894282 ABM85208 GU727630 ADU87632 J03191 AAA36486 NM_005022 NP_005013
Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. {ECO:0000269|PubMed:18573880}.
Subcellular Location	Cytoplasm, cytoskeleton.
Tissue Specificity	Expressed in epididymis (at protein level). {ECO:0000269|PubMed:20736409}.
Top Pathways	Salmonella infection, Rap1 signaling pathway, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PFN1 Gene cDNA Clone - orb144715 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-PFN1-cDNA-Clone - DC00967 from Abgent, a WuXi AppTec company Prices $189.00 Sizes 10 µg Species Human Accession BC002475

PFN1 - MBS1276945 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC002475

Human PFN1/Profilin 1 Gene ORF cDNA clone in cloning vector - HG14329-G from Sino Biological Species Human

Human PFN1/Profilin 1 Gene ORF cDNA clone expression plasmid, C-His tag - HG14329-CH from Sino Biological Species Human

Human PFN1/Profilin 1 Gene ORF cDNA clone expression plasmid - HG14329-UT from Sino Biological Species Human

Human PFN1/Profilin 1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG14329-CY from Sino Biological Species Human

Human PFN1/Profilin 1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14329-NF from Sino Biological Species Human

Human PFN1/Profilin 1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14329-NM from Sino Biological Species Human

Human PFN1/Profilin 1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14329-ACR from Sino Biological Species Human

Human PFN1/Profilin 1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG14329-ANR from Sino Biological Species Human

Human PFN1/Profilin 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14329-CF from Sino Biological Species Human

Human PFN1/Profilin 1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14329-CM from Sino Biological Species Human

Human PFN1/Profilin 1 Gene ORF cDNA clone expression plasmid, N-His tag - HG14329-NH from Sino Biological Species Human

Human PFN1/Profilin 1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG14329-ANG from Sino Biological Species Human

Human PFN1/Profilin 1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG14329-ACG from Sino Biological Species Human

Human PFN1/Profilin 1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG14329-NY from Sino Biological Species Human

Human PFN1 ORF Clone (BC002475) - CDCS412060 from Creative biogene Species Human Accession P07737

Human PFN1 ORF clone (BC002475) - CDCB159174 from Creative biogene Species Human

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