NPL

Gene Symbol	NPL
Entrez Gene	80896
Alt Symbol	C112, C1orf13, NAL, NPL1
Species	Human
Gene Type	protein-coding
Description	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
Other Description	N-acetylneuraminate lyase|N-acetylneuraminic acid aldolase|NALase|dihydrodipicolinate synthetase homolog 1|sialate-pyruvate lyase|sialic acid aldolase
Swissprots	Q6PEL0 Q4G0Z2 Q4G0Q8 B2R839 Q9BXD5 Q64L88
Accessions	EAW91132 EAW91133 EAW91134 EAW91135 Q9BXD5 AF338436 AAK25795 AI249145 AK297017 BAG59549 AK301068 BAG62675 AK313225 BAG36036 AL525867 AY336748 AAQ82432 BC034966 BC042003 BC058003 AAH58003 BC125051 AAI25052 CB961482 NM_001200050 NP_001186979 NM_001200051 NP_001186980 NM_001200052 NP_001186981 NM_001200056 NP_001186985 NM_030769 NP_110396
Function	Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N- glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	Isoform 2 is expressed in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocyte. {ECO:0000269|PubMed:16147865}.
Top Pathways	Amino sugar and nucleotide sugar metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NPL full length protein - ab106873 from Abcam Category Protein Source E. coli Species Human

NPL / C112 Antibody Blocking Peptide - LS-E6238 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NPL / C112 Antibody Blocking Peptide - LS-E23066 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NPL Recombinant Protein - H00080896-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Bacterial NPL Protein - NBP2-22652 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli

Recombinant Human NPL Protein - NBP1-51091 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

NPL-Antibody-N-term-Blocking-Peptide - BP18910a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human NPL protein - orb168939 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

NPL protein (His tag) - 80R-1785 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

NPL (1-320, His-tag) - AR09968PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

NPL (1-320, His-tag) - AR09968PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

NPL - H00080896-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NPL - H00080896-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

N-acetylneuraminate Pyruvate Lyase, Human Recombinant - 228-12276-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

N-Acetylneuraminate Lyase E.Coli Recombinant - 228-12279-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Escherichia coli

Recombinant N-Acetylneuraminate Lyase E.Coli - 228-12279-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Escherichia coli

Recombinant N-Acetylneuraminate Lyase E.Coli - 228-12279-3 from RayBiotech Category Protein Prices $2,880.00 Sizes 3 µg Source Escherichia Coli. Species Escherichia coli

NPL, 1-320aa, Human, His tag, E.coli - 01-P1028 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

NPL fusion protein - Ag9932 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

NPL fusion protein - Ag10137 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human NPPB Protein - BP001678-C154 from Syd Labs Category Protein Prices $126.00, $378.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

NPL, 1-320aa, Recombinant Protein - GWB-P1010I from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

NPL Human Protein - GWB-BSP258 from Genway Biotech Category Protein Prices $75.00, $165.00, $3,230.00 Sizes 5 μg, 20 μg, 1000 μg Source Escherichia Coli. Species Human

Recombinant Human NPL, His-tagged - NPL-981H from Creative Biomart Category Protein

Recombinant Human NPL, His-tagged - NPL-1344H from Creative Biomart Category Protein Source E.coli Species Human

Search more