Gene Symbol | NPL |
---|---|
Entrez Gene | 80896 |
Alt Symbol | C112, C1orf13, NAL, NPL1 |
Species | Human |
Gene Type | protein-coding |
Description | N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) |
Other Description | N-acetylneuraminate lyase|N-acetylneuraminic acid aldolase|NALase|dihydrodipicolinate synthetase homolog 1|sialate-pyruvate lyase|sialic acid aldolase |
Swissprots | Q6PEL0 Q4G0Z2 Q4G0Q8 B2R839 Q9BXD5 Q64L88 |
Accessions | EAW91132 EAW91133 EAW91134 EAW91135 Q9BXD5 AF338436 AAK25795 AI249145 AK297017 BAG59549 AK301068 BAG62675 AK313225 BAG36036 AL525867 AY336748 AAQ82432 BC034966 BC042003 BC058003 AAH58003 BC125051 AAI25052 CB961482 NM_001200050 NP_001186979 NM_001200051 NP_001186980 NM_001200052 NP_001186981 NM_001200056 NP_001186985 NM_030769 NP_110396 |
Function | Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N- glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | Isoform 2 is expressed in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocyte. {ECO:0000269|PubMed:16147865}. |
Top Pathways | Amino sugar and nucleotide sugar metabolism |
NPL CRISPR/Cas9 KO Plasmid (h) - sc-408289 from Santa Cruz Biotechnology
|
||||||||
NPL HDR Plasmid (h) - sc-408289-HDR from Santa Cruz Biotechnology
|
||||||||
NPL Double Nickase Plasmid (h) - sc-408289-NIC from Santa Cruz Biotechnology
|
||||||||
NPL Double Nickase Plasmid (h2) - sc-408289-NIC-2 from Santa Cruz Biotechnology
|
||||||||
NPL CRISPR Activation Plasmid (h) - sc-408289-ACT from Santa Cruz Biotechnology
|
||||||||
NPL CRISPR Activation Plasmid (h2) - sc-408289-ACT-2 from Santa Cruz Biotechnology
|
||||||||
NPL Lentiviral Activation Particles (h) - sc-408289-LAC from Santa Cruz Biotechnology
|
||||||||
NPL Lentiviral Activation Particles (h2) - sc-408289-LAC-2 from Santa Cruz Biotechnology
|
||||||||
NPL siRNA (h) - sc-88481 from Santa Cruz Biotechnology
|
||||||||
NPL shRNA Plasmid (h) - sc-88481-SH from Santa Cruz Biotechnology
|
||||||||
NPL shRNA (h) Lentiviral Particles - sc-88481-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU033561 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN15458 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15458 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR04088 from Sigma-Aldrich
|
||||||||
NPL siRNA (Human) - CRJ2940 from Cohesion Biosciences
|
||||||||
shRNA set against Human NPL (NM_030769.2) - SHH354288 from Creative biogene
|
||||||||
NPL shRNA Plasmid (Human) - CHJ2940 from Cohesion Biosciences
|
||||||||
NPL miRNA 3'UTR clone - MiUTR3H-11857 from Creative biogene
|