E2F1

Gene Symbol	E2F1
Entrez Gene	1869
Alt Symbol	E2F-1, RBAP1, RBBP3, RBP3
Species	Human
Gene Type	protein-coding
Description	E2F transcription factor 1
Other Description	PBR3|PRB-binding protein E2F-1|RBAP-1|RBBP-3|retinoblastoma-associated protein 1|retinoblastoma-binding protein 3|transcription factor E2F1
Swissprots	Q13143 Q92768 Q01094
Accessions	AAC50719 AAD14150 AAM47604 CAM91159 CAN37617 CAY56011 CBX53852 EAW76299 EAW76300 Q01094 AF086380 BC005098 AAH05098 BC050369 AAH50369 BC058902 AAH58902 M96577 AAA35782 S49592 AAB24289 NM_005225 NP_005216
Function	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). {ECO:0000250|UniProtKB:Q61501, ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:8170954}.
Subcellular Location	Nucleus.
Top Pathways	MicroRNAs in cancer, Cell cycle, HTLV-I infection, Prostate cancer, Glioma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human E2F1 full length protein - ab82207 from Abcam Category Protein Source Baculovirus infected insect cells Species Human

Human E2F1 protein fragment - ab152349 from Abcam Category Protein Source Wheat germ Species Human

E2F1 Antibody Blocking Peptide - LS-E10861 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

E2F1 Antibody Blocking Peptide - LS-E10591 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

E2F1 Antibody Blocking Peptide - LS-E7399 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

E2F1 Antibody Blocking Peptide - LS-E7462 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

E2F1 Antibody Blocking Peptide - LS-E7270 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

E2F1 Antibody Blocking Peptide - LS-E9083 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

E2F1 Antibody Blocking Peptide - LS-E9084 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RBP3 / IRBP Antibody Blocking Peptide - LS-E5323 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RBP3 Protein - H00005949-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human E2F-1 Protein - H00001869-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

E2F-1 Peptide - P1618 from Novus Biologicals Category Peptide Species Human

E2F-1 Peptide - P1311 from Novus Biologicals Category Peptide Species Human

E2F-1 Peptide - P2603 from Novus Biologicals Category Peptide Species Human

Phospho-E2F1S337-Antibody-Blocking-peptide - BP3091a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-E2F1S332-Antibody-Blocking-peptide - BP3485a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-E2F1H357-Antibody-Blocking-peptide - BP3698a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

E2F1-Antibody-Center-Blocking-peptide - BP7593d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

E2F1-Antibody-H357-Blocking-Peptide - BP7593c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

E2F1-Antibody-S332-Blocking-Peptide - BP7593b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Biotinylated-E2F1-S337-Non-phospho-Control-Peptide - SP2034d from Abgent, a WuXi AppTec company Category Peptide Prices $150.00 Sizes 1 mg

E2F1-S337-Non-phospho-Control-Peptide - SP2034c from Abgent, a WuXi AppTec company Category Peptide Prices $132.00 Sizes 1 mg

Biotinylated-E2F1-S337-Phospho-Peptide - SP2034b from Abgent, a WuXi AppTec company Category Peptide Prices $300.00 Sizes 1 mg

E2F1-S337-Phospho-Peptide - SP2034a from Abgent, a WuXi AppTec company Category Peptide Prices $150.00 Sizes 1 mg

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