E2F1

Gene Symbol E2F1
Entrez Gene 1869
Alt Symbol E2F-1, RBAP1, RBBP3, RBP3
Species Human
Gene Type protein-coding
Description E2F transcription factor 1
Other Description PBR3|PRB-binding protein E2F-1|RBAP-1|RBBP-3|retinoblastoma-associated protein 1|retinoblastoma-binding protein 3|transcription factor E2F1
Swissprots Q13143 Q92768 Q01094
Accessions AAC50719 AAD14150 AAM47604 CAM91159 CAN37617 CAY56011 CBX53852 EAW76299 EAW76300 Q01094 AF086380 BC005098 AAH05098 BC050369 AAH50369 BC058902 AAH58902 M96577 AAA35782 S49592 AAB24289 NM_005225 NP_005216
Function Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). {ECO:0000250|UniProtKB:Q61501, ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:8170954}.
Subcellular Location Nucleus.
Top Pathways MicroRNAs in cancer, Cell cycle, HTLV-I infection, Prostate cancer, Glioma

E2F-1 Antibody - 3742 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western Blot analysis of extracts from HeLa, SK-N-MC, and A-673 cells using E2F-1 Antibody.

E2F-1 (C-20) - sc-193 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
E2F-1 (C-20): sc-193. Western blot analysis of BALB/3T3 cells transfected with either y-CRE (A) or y-CRE/E2F (B).

E2F-1 (C-7) - sc-137059 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2F-1 (C-7): sc-137059. Western blot analysis of E2F-1 expression in non-transfected: sc-117752 (A) and human E2F-1 transfected: sc-116659 (B) 293T whole cell lysates.

E2F-1 (H-137) - sc-22820 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
E2F-1 (H-137): sc-22820. Immunoperoxidase staining of formalin fixed, paraffin-embedded human spleen tissue showing nuclear localization.

E2F-1 (D-10) - sc-137110 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2F-1 (D-10): sc-137110. Western blot analysis of E2F-1 expression in non-transfected: sc-117752 (A) and human E2F-1 transfected: sc-116659 (B) 293T whole cell lysates.

E2F-1 (KH129) - sc-56661 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2F-1 (KH129): sc-56661. Western blot analysis of E2F-1 expression in MOLT-4 (A), HeLa (B), HEL 92.1.7 (C) and NAMALWA (D) whole cell lysates and K-562 (E) and HeLa (F) nuclear extracts.

E2F-1 (KH20) - sc-56662 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2F-1 (KH20): sc-56662. Western blot analysis of E2F-1 expression in MOLT-4 (A), HeLa (B), HEL 92.1.7 (C) and NAMALWA (D) whole cell lysates and K-562 (E) and HeLa (F) nuclear extracts.

E2F-1 (E-2) - sc-137060 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2F-1 (E-2): sc-137060. Western blot analysis of E2F-1 expression in non-transfected: sc-117752 (A) and human E2F-1 transfected: sc-116659 (B) 293T whole cell lysates.

E2F-1 (KH95) - sc-251 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2F-1 (KH95): sc-251. Western blot analysis of E2F-1 expression in HeLa (A) and K-562 (B) nuclear extracts.

p-E2F-1 (Ser 337) - sc-130188 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-E2F-1 (Ser 337): sc-130188. Immunofluorescence staining of methanol-fixed Hep G2 cells showing cytoplasmic localization.

Anti-E2F1 (phospho S337) antibody - ab135549 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-E2F1 (phospho S337) antibody (ab135549) at 1/100 dilutionLane 1 : T47D cell lysateLane 2 : HepG2 cell lysateLane 3 : A2058 cell lysateLysates/proteins at 12.5 µg per lane.

Anti-E2F1 (phospho S364) antibody - ab5391 from Abcam

Prices $382.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-E2F1 (phospho S364) antibody (ab5391) at 1/250 dilutionLane 1 : CRE (mouse) cells transfected with human E2F1 Lane 2 : CRE (mouse) cells transfected with human E2F1 with doxorubicinLane 3 : NiH3T3 (mouse) cell lysateLane 4 : NiH3T3 (mouse) cell lysate with doxorubicinLane 5 : MDA-231 (human breast cancer) cell lysate Lane 6 : MDA-231 (human breast cancer) cell lysate with doxorubicinSecondaryHRP conjugated Goat-anti-Rabbit IgG MX10

Anti-E2F1 (phospho S364) antibody [2] - ab122888 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2
All lanes : Anti-E2F1 (phospho S364) antibody [2] (ab122888) at 1 µg/mlLane 1 : Untreated MCF cells immunoprecipitated with a pantropic anti-E2F1 antibodyLane 2 : MCF cells treated with etoposide at 10 µM for 16 h, immunoprecipitated with a pantropic anti-E2F1 antibodyLane 3 : MCF cells treated with etoposide at 10 µM for 16 h

Anti-E2F1 (phospho T433) antibody - ab55325 from Abcam

Prices $380.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-E2F1 (phospho T433) antibody (ab55325) at 1/500 dilutionLane 1 : HeLa cell extract treated with Etoposide (at 25µM for 24 hrs).Lane 2 : HeLa cell extract treated with Etoposide (at 25µM for 24 hrs), and with the immunising phosphopeptide.

Anti-E2F1 (phospho T433) antibody - ab195816 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-E2F1 (phospho T433) antibody (ab195816) at 1/500 dilutionLane 1 : Etoposide treated Hela whole cell lysate with antigen-specific peptideLane 2 : Etoposide treated Hela whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-E2F1 antibody - ab483 from Abcam

Prices $373.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-E2F1 antibody - ab94888 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-E2F1 antibody (ab94888) at 1/500 dilution + K562 cell lysate

Anti-E2F1 antibody - ab55398 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-E2F1 antibody (ab55398) at 1/500 dilutionLane 1 : HeLa cell extract, treated with Etoposide, without the immunizing peptideLane 2 : HeLa cell extract, treated with Etoposide, with the immunizing peptide

Anti-E2F1 antibody - ab96864 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-E2F1 antibody (ab96864) at 1/1000 dilutionLane 1 : A431 whole cell lysateLane 2 : H1299 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-E2F1 antibody - ab14768 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-E2F1 antibody (ab14768) at 1/500 dilutionLane 1 : HeLa cell extract, whole cell lysateLane 2 : HeLa cell extract, nuclear lysateLysates/proteins at 50 µg per lane.SecondaryHRP conjugated goat anti-rabbit antibody

Anti-E2F1 antibody - ab100 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-E2F1 antibody - ab75950 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-E2F1 antibody (ab75950) at 1/50 dilution + 293 cell line lysate at 35 µg

Anti-E2F1 antibody - ab11837 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-E2F1 antibody - ab181473 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-E2F1 antibody (ab181473) at 1 µg/ml + HeLa nuclear lysate in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-E2F1 antibody [6B5] - ab101 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6B5
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