| Gene Symbol |
XDH
|
| Entrez Gene |
7498
|
| Alt Symbol |
XO, XOR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
xanthine dehydrogenase
|
| Other Description |
xanthine dehydrogenase/oxidase|xanthine oxidoreductase
|
| Swissprots |
Q4PJ16 Q16712 Q16681 P47989
|
| Accessions |
AAF15890 AAX76512 AAY68219 CAW36700 CAW39049 CAW41215 CAW47231 CAW63651 CAW71881 CAW80373 CAW82865 CAW86283 CAY77138 CBC02653 CBC04906 CBC06866 CBC13019 CBC45853 CBC62270 CBC79202 CBC84152 CBC89109 EAX00479 P47989 AK130114 BC166696 AAI66696 CV574002 D11456 BAA02013 U06117 AAA75287 U39487 AAB08399 XM_011533095 XP_011531397 XM_011533096 XP_011531398 NM_000379 NP_000370
|
| Function |
Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). {ECO:0000269|PubMed:17301077}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Peroxisome {ECO:0000250}. Secreted.
|
| Tissue Specificity |
Detected in milk (at protein level). {ECO:0000269|Ref.12}.
|
| Top Pathways |
Peroxisome, Caffeine metabolism, Purine metabolism, Drug metabolism - other enzymes
|
![Western Blot: Xanthine Oxidase Overexpression Lysate (Adult Normal) [NBL1-17903] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Xanthine Oxidase.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9183_Xanthine%2520Oxidase%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17903-img0002.jpg)