Gene Symbol | CORO1A |
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Entrez Gene | 11151 |
Alt Symbol | CLABP, CLIPINA, HCORO1, IMD8, TACO, p57 |
Species | Human |
Gene Type | protein-coding |
Description | coronin, actin binding protein, 1A |
Other Description | clipin-A|coronin-1|coronin-1A|coronin-like protein A|coronin-like protein p57|tryptophan aspartate-containing coat protein |
Swissprots | B2RBL1 P31146 Q2YD73 |
Accessions | EAW79906 EAW79907 EAW79908 EAW79909 EAW79910 P31146 AB209221 BAD92458 AF495470 AAM18516 AK096332 AK097964 AK123401 BAC85606 AK296207 BAG58933 AK314714 BAG37258 BC110374 AAI10375 BC126385 AAI26386 BC126387 AAI26388 CD623635 D44497 BAA07940 DA256300 DC408372 EU446773 ABZ92302 GQ214031 HQ258407 ADR83161 U34690 AAA77058 X89109 CAA61482 XM_011545714 XP_011544016 NM_001193333 NP_001180262 NM_007074 NP_009005 |
Function | May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. {ECO:0000269|PubMed:10338208}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity). {ECO:0000250}. |
Tissue Specificity | Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut. |
Top Pathways | Phagosome, Tuberculosis |
Human Coronin 1a protein fragment - ab161325 from Abcam
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CORO1A / Coronin 1a Antibody Blocking Peptide - LS-E25585 from LifeSpan Bioscience
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CORO1A / Coronin 1a Antibody Blocking Peptide - LS-E12135 from LifeSpan Bioscience
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CORO1A / Coronin 1a Antibody Blocking Peptide - LS-E14012 from LifeSpan Bioscience
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Recombinant Human Coronin-1a Protein - H00011151-Q01 from Novus Biologicals
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Coronin 1A blocking peptide - GTX89757-PEP from GeneTex
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Human Coronin 1A Protein - abx066127 from Abbexa
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Coronin 1A Peptide - AC21-0414-P from Abcore
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Coronin-1A - H00011151-Q01-10 from Acris Antibodies
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Coronin-1A - H00011151-Q01-25 from Acris Antibodies
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Coronin 1 Peptide - 45-421P from ProSci
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CORO1A fusion protein - ag12385 from Proteintech Group
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CORO1A fusion protein - ag12139 from Proteintech Group
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Recombinant Coronin 1A (CORO1A) - RPJ355Hu01 from Uscn Life Science Inc.
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Recombinant Coronin 1A (CORO1A) - RPJ355Ra01 from Uscn Life Science Inc.
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Recombinant Coronin 1A (CORO1A) - RPJ355Hu01 from Cloud-clone
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Recombinant Human Coronin-1A(CORO1A) - CSB-YP005813HU CSB-EP005813HU CSB-BP005813HU CSB-MP005813HU from Cusabio
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Coronin-1A - TP310753 from Acris Antibodies
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Coronin 1/TACO, Peptide - MBS425037 from MyBioSource
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Coronin-1a Recombinant Protein Antigen - NBP2-13861PEP from Novus Biologicals
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Clipin A Blocking Peptide - abx061058 from Abbexa
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CORO1A-Antibody-C-term-Blocking-Peptide - BP6890b from Abgent, a WuXi AppTec company
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CORO1A Peptide, Human - M34GP03518H from Creative Peptides
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Clipin A Blocking Peptide - CBP4971 from Cohesion Biosciences
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CORO1A Recombinant Protein (OPCD02360) - OPCD02360 from Aviva Systems Biology
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