Gene Symbol | GTF2IRD1 |
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Entrez Gene | 9569 |
Alt Symbol | BEN, CREAM1, GTF3, MUSTRD1, RBAP2, WBS, WBSCR11, WBSCR12, hMusTRD1alpha1 |
Species | Human |
Gene Type | protein-coding |
Description | GTF2I repeat domain containing 1 |
Other Description | USE B1-binding protein|Williams-Beuren syndrome chromosome region 11|binding factor for early enhancer|general transcription factor 3|general transcription factor II-I repeat domain-containing protein 1|general transcription factor III|muscle TFII-I repeat domain-containing protein 1 alpha 1|slow-muscle-fiber enhancer-binding protein|williams-Beuren syndrome chromosomal region 12 protein |
Swissprots | Q9UHK8 Q8WVC4 Q9UHL9 Q9UI91 Q86UM3 O95444 Q75MX7 Q6DSU6 |
Accessions | AAP21877 AAS00361 AAS00362 EAW69599 EAW69600 EAW69601 Q9UHL9 AB209389 BAD92626 AF089107 AAF21796 AF104923 AAD27668 AF118270 AAD14687 AF151354 AAF19786 AF156489 AAF17358 AK308242 AY648295 AAT68469 BC018136 AAH18136 DQ891171 ABM82097 DQ894354 ABM85280 XM_006716182 XP_006716245 XM_006716183 XP_006716246 XM_011516713 XP_011515015 NM_001199207 NP_001186136 NM_005685 NP_005676 NM_016328 NP_057412 |
Function | May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus. |
Tissue Specificity | Highly expressed in adult skeletal muscle, heart, fibroblast, bone and fetal tissues. Expressed at lower levels in all other tissues tested. |
Top Pathways | Herpes simplex infection, cGMP-PKG signaling pathway, Basal transcription factors |
WBSCR11 CRISPR/Cas9 KO Plasmid (h) - sc-405974 from Santa Cruz Biotechnology
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WBSCR11 HDR Plasmid (h) - sc-405974-HDR from Santa Cruz Biotechnology
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WBSCR11 Double Nickase Plasmid (h) - sc-405974-NIC from Santa Cruz Biotechnology
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WBSCR11 Double Nickase Plasmid (h2) - sc-405974-NIC-2 from Santa Cruz Biotechnology
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WBSCR11 CRISPR Activation Plasmid (h) - sc-405974-ACT from Santa Cruz Biotechnology
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WBSCR11 CRISPR Activation Plasmid (h2) - sc-405974-ACT-2 from Santa Cruz Biotechnology
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WBSCR11 Lentiviral Activation Particles (h) - sc-405974-LAC from Santa Cruz Biotechnology
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WBSCR11 Lentiviral Activation Particles (h2) - sc-405974-LAC-2 from Santa Cruz Biotechnology
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WBSCR11 siRNA (h) - sc-38621 from Santa Cruz Biotechnology
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WBSCR11 shRNA Plasmid (h) - sc-38621-SH from Santa Cruz Biotechnology
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WBSCR11 shRNA (h) Lentiviral Particles - sc-38621-V from Santa Cruz Biotechnology
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GTF2IRD1 RNAi - H00009569-R01 from Novus Biologicals
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MISSION® esiRNA - EHU043171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9771 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9771 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00713 from Sigma-Aldrich
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GTF2IRD1 siRNA (Human) - CRH6366 from Cohesion Biosciences
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GTF2IRD1 RNAi - H00009569-R02 from Novus Biologicals
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GTF2IRD1 - MBS8233327 from MyBioSource
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shRNA set against Human GTF2IRD1 (NM_005685.3) - SHH309002 from Creative biogene
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Human GTF2IRD1 siRNA - orb266868 from Biorbyt
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GTF2IRD1 shRNA Plasmid (Human) - CHH6366 from Cohesion Biosciences
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GTF2IRD1 miRNA 3'UTR clone - MiUTR3H-06710 from Creative biogene
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GTF2IRD1 miRNA 3'UTR clone - MiUTR3H-06711 from Creative biogene
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