Gene Symbol | GTF2IRD1 |
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Entrez Gene | 9569 |
Alt Symbol | BEN, CREAM1, GTF3, MUSTRD1, RBAP2, WBS, WBSCR11, WBSCR12, hMusTRD1alpha1 |
Species | Human |
Gene Type | protein-coding |
Description | GTF2I repeat domain containing 1 |
Other Description | USE B1-binding protein|Williams-Beuren syndrome chromosome region 11|binding factor for early enhancer|general transcription factor 3|general transcription factor II-I repeat domain-containing protein 1|general transcription factor III|muscle TFII-I repeat domain-containing protein 1 alpha 1|slow-muscle-fiber enhancer-binding protein|williams-Beuren syndrome chromosomal region 12 protein |
Swissprots | Q9UHK8 Q8WVC4 Q9UHL9 Q9UI91 Q86UM3 O95444 Q75MX7 Q6DSU6 |
Accessions | AAP21877 AAS00361 AAS00362 EAW69599 EAW69600 EAW69601 Q9UHL9 AB209389 BAD92626 AF089107 AAF21796 AF104923 AAD27668 AF118270 AAD14687 AF151354 AAF19786 AF156489 AAF17358 AK308242 AY648295 AAT68469 BC018136 AAH18136 DQ891171 ABM82097 DQ894354 ABM85280 XM_006716182 XP_006716245 XM_006716183 XP_006716246 XM_011516713 XP_011515015 NM_001199207 NP_001186136 NM_005685 NP_005676 NM_016328 NP_057412 |
Function | May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus. |
Tissue Specificity | Highly expressed in adult skeletal muscle, heart, fibroblast, bone and fetal tissues. Expressed at lower levels in all other tissues tested. |
Top Pathways | Herpes simplex infection, cGMP-PKG signaling pathway, Basal transcription factors |
WBSCR11 (M-19) - sc-14714 from Santa Cruz Biotechnology
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WBSCR11 (G-16) - sc-14710 from Santa Cruz Biotechnology
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WBSCR11 (D-19) - sc-14711 from Santa Cruz Biotechnology
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WBSCR11 (GTF5I102) - sc-81425 from Santa Cruz Biotechnology
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Anti-GTF2IRD1 antibody - ab55975 from Abcam
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Anti-GTF2IRD1 antibody - ab64805 from Abcam
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Anti-GTF2IRD1 antibody - ab84568 from Abcam
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Anti-GTF2IRD1 antibody [GTF5I102] - ab51524 from Abcam
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Anti-GTF3 / GTF2IRD1 Antibody (aa650-700) - LS-C288141 from LifeSpan Bioscience
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Anti-GTF3 / GTF2IRD1 Antibody - LS-C66476 from LifeSpan Bioscience
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Anti-GTF3 / GTF2IRD1 Antibody (aa467-480) - LS-C54950 from LifeSpan Bioscience
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Anti-GTF3 / GTF2IRD1 Antibody (aa431-531, clone 10C349, Azide-free) - LS-C183649 from LifeSpan Bioscience
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Anti-GTF3 / GTF2IRD1 Antibody (aa79-108, APC) - LS-C236022 from LifeSpan Bioscience
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Anti-GTF3 / GTF2IRD1 Antibody (aa79-108, AP) - LS-C236023 from LifeSpan Bioscience
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Anti-GTF3 / GTF2IRD1 Antibody (aa79-108, Biotin) - LS-C236024 from LifeSpan Bioscience
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Anti-GTF3 / GTF2IRD1 Antibody (aa79-108, FITC) - LS-C236025 from LifeSpan Bioscience
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Anti-GTF3 / GTF2IRD1 Antibody (aa757-806) - LS-C31821 from LifeSpan Bioscience
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Anti-GTF3 / GTF2IRD1 Antibody (aa79-108, PE) - LS-C236026 from LifeSpan Bioscience
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Anti-GTF3 / GTF2IRD1 Antibody (aa873-922) - LS-C31823 from LifeSpan Bioscience
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Anti-GTF3 / GTF2IRD1 Antibody (aa71-120) - LS-C119311 from LifeSpan Bioscience
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Anti-GTF3 / GTF2IRD1 Antibody (N-Terminus) - LS-C31822 from LifeSpan Bioscience
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Anti-GTF3 / GTF2IRD1 Antibody - LS-C310559 from LifeSpan Bioscience
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Anti-GTF3 / GTF2IRD1 Antibody - LS-C308150 from LifeSpan Bioscience
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Anti-GTF3 / GTF2IRD1 Antibody (aa79-108, Azide-free, HRP) - LS-C249145 from LifeSpan Bioscience
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Anti-GTF3 / GTF2IRD1 Antibody (aa431-530) - LS-C308152 from LifeSpan Bioscience
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