KCNA4

Gene Symbol	KCNA4
Entrez Gene	3739
Alt Symbol	HBK4, HK1, HPCN2, HUKII, KCNA4L, KCNA8, KV1.4, PCN2
Species	Human
Gene Type	protein-coding
Description	potassium channel, voltage gated shaker related subfamily A, member 4
Other Description	cardiac potassium channel|fetal skeletal muscle potassium channel|potassium channel 2|potassium voltage-gated channel subfamily A member 4|potassium voltage-gated channel, shaker-related subfamily, member 4|rapidly inactivating potassium channel|shaker-related potassium channel Kv1.4|type A potassium channel|voltage-gated K(+) channel HuKII|voltage-gated potassium channel HBK4|voltage-gated potassium channel HK1|voltage-gated potassium channel subunit Kv1.4
Swissprots	P22459
Accessions	P22459 AK311228 AK313662 BC166685 AAI66685 BE467209 DA328650 L02751 AAA36140 M55514 AAA60034 M60450 AAA61275 NM_002233 NP_002224
Function	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any partic
Subcellular Location	Cell membrane {ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:19912772, ECO:0000269|PubMed:19968958, ECO:0000269|PubMed:8495559}; Multi-pass membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:P15385}.
Tissue Specificity	Detected in heart ventricle. {ECO:0000269|PubMed:2001794}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Kv1.4 protein fragment - ab152487 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human Kv1.4 Protein - H00003739-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

KCNA4 - H00003739-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

KCNA4 - H00003739-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Potassium voltage-gated channel subfamily A member 4 (KCNA4), Recombinant Protein - MBS965237 from MyBioSource Category Protein Prices $1,375.00, $1,835.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Kv1.4 Protein - NBP1-89691PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

KCNA4-Blocking-Peptide-C-term - BP19983b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

KCNA4 Peptide, Human - M34GP07923H from Creative Peptides Category Peptide Source Synthetic. Species Human

Potassium voltage-gated channel subfamily A member 4 (KCNA4), Recombinant Protein - MBS7017613 from MyBioSource Category Protein Prices $1,120.00, $2,105.00, $3,310.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

Search more