KCNA4
| Gene Symbol | KCNA4 |
|---|---|
| Entrez Gene | 3739 |
| Alt Symbol | HBK4, HK1, HPCN2, HUKII, KCNA4L, KCNA8, KV1.4, PCN2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | potassium channel, voltage gated shaker related subfamily A, member 4 |
| Other Description | cardiac potassium channel|fetal skeletal muscle potassium channel|potassium channel 2|potassium voltage-gated channel subfamily A member 4|potassium voltage-gated channel, shaker-related subfamily, member 4|rapidly inactivating potassium channel|shaker-related potassium channel Kv1.4|type A potassium channel|voltage-gated K(+) channel HuKII|voltage-gated potassium channel HBK4|voltage-gated potassium channel HK1|voltage-gated potassium channel subunit Kv1.4 |
| Swissprots | P22459 |
| Accessions | P22459 AK311228 AK313662 BC166685 AAI66685 BE467209 DA328650 L02751 AAA36140 M55514 AAA60034 M60450 AAA61275 NM_002233 NP_002224 |
| Function | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any partic |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:19912772, ECO:0000269|PubMed:19968958, ECO:0000269|PubMed:8495559}; Multi-pass membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:P15385}. |
| Tissue Specificity | Detected in heart ventricle. {ECO:0000269|PubMed:2001794}. |
KV1.4 CRISPR/Cas9 KO Plasmid (h) - sc-405990 from Santa Cruz Biotechnology
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KV1.4 HDR Plasmid (h) - sc-405990-HDR from Santa Cruz Biotechnology
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KV1.4 Double Nickase Plasmid (h) - sc-405990-NIC from Santa Cruz Biotechnology
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KV1.4 Double Nickase Plasmid (h2) - sc-405990-NIC-2 from Santa Cruz Biotechnology
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KV1.4 CRISPR Activation Plasmid (h) - sc-405990-ACT from Santa Cruz Biotechnology
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KV1.4 CRISPR Activation Plasmid (h2) - sc-405990-ACT-2 from Santa Cruz Biotechnology
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KV1.4 Lentiviral Activation Particles (h) - sc-405990-LAC from Santa Cruz Biotechnology
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KV1.4 Lentiviral Activation Particles (h2) - sc-405990-LAC-2 from Santa Cruz Biotechnology
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KV1.4 siRNA (h) - sc-42714 from Santa Cruz Biotechnology
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KV1.4 shRNA Plasmid (h) - sc-42714-SH from Santa Cruz Biotechnology
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KV1.4 shRNA (h) Lentiviral Particles - sc-42714-V from Santa Cruz Biotechnology
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Kv1.4 RNAi - H00003739-R01 from Novus Biologicals
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MISSION® esiRNA - EHU041441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10919 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10919 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04296 from Sigma-Aldrich
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KCNA4 siRNA (Human) - CRH2516 from Cohesion Biosciences
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KCNA4, siRNA - MBS8205817 from MyBioSource
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shRNA set against Human KCNA4 (NM_002233.3) - SHH322723 from Creative biogene
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Human KCNA4 siRNA - orb263018 from Biorbyt
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KCNA4 shRNA Plasmid (Human) - CHH2516 from Cohesion Biosciences
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KCNA4 miRNA 3'UTR clone - MiUTR3H-01799 from Creative biogene
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