Gene Symbol | Ace |
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Entrez Gene | 11421 |
Alt Symbol | AW208573, CD143 |
Species | Mouse |
Gene Type | protein-coding |
Description | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 |
Other Description | angiotensin-converting enzyme|dipeptidyl carboxypeptidase I|dipeptidyl peptidase|kininase II |
Swissprots | P09470 Q6GTS2 P22967 |
Accessions | AAA37151 AAP03650 EDL34253 EDL34254 EDL34255 P09470 AK087056 BAC39791 AK154632 BAE32728 AK161020 BAE36151 AK164780 BC034367 AAH34367 BC040404 AAH40404 BC052531 AAH52531 BC083109 AAH83109 BC110362 AAI10363 BY197083 BY210311 J03940 AAA37146 J04946 AAA37147 J04947 AAA37148 M55333 AAA37149 NM_001281819 NP_001268748 NM_009598 NP_033728 NM_207624 NP_997507 |
Function | Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm. {ECO:0000269|PubMed:15665832, ECO:0000269|PubMed:7753170, ECO:0000269|PubMed:8642790}. |
Subcellular Location | Angiotensin-converting enzyme, soluble form: Secreted {ECO:0000250}. |
Tissue Specificity | Testis-specific isoform is expressed in spermatocytes, adult testis. |
Top Pathways | Hypertrophic cardiomyopathy (HCM), Chagas disease (American trypanosomiasis), Renin-angiotensin system |
Anti-Angiotensin Converting Enzyme 1 antibody [RM0069-9B21] - ab86469 from Abcam
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ACE/CD143 Antibody [Unconjugated] - AF1513 from Novus Biologicals
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ACE/CD143 Antibody (230214) [Unconjugated] - MAB15131 from Novus Biologicals
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ACE/CD143 Antibody (RM0069-9B21) - NBP1-21518 from Novus Biologicals
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ACE/CD143 Antibody [Biotin] - BAF1513 from Novus Biologicals
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ACE antibody [9B21] - GTX53158 from GeneTex
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Anti -ACE (ADCP, DCP1, Angiotensin-converting enzyme, Dipeptidyl carboxypeptidase I,Kininase II, Angiotensin-converting enzyme, soluble form) - 030735 from USBiological Life Science
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Anti -ACE (Angiotensin-Converting Enzyme, CD143) - 216101 from USBiological Life Science
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ACE Antibody - abx025482 from Abbexa
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ACE Antibody - abx103104 from Abbexa
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ACE / CD143 antibody - DM3531P from Acris Antibodies
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Anti-Angiotensin I Converting Enzyme (ACE) - 20-2006 from ARP American Research Products
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Angiotensin-converting Enzyme (CD143), Monoclonal Antibody - MBS690399 from MyBioSource
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ACE Antibody (FITC) - GWB-F28BAA from Genway Biotech
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ACE Antibody - GWB-EA4A30 from Genway Biotech
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ACE Antibody - GWB-AD5F8C from Genway Biotech
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ACE Antibody (Biotin) - GWB-949E7C from Genway Biotech
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ACE Antibody - GWB-62A40E from Genway Biotech
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ACE Antibody (Biotin) - GWB-48D1C2 from Genway Biotech
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ACE Antibody (FITC) - GWB-2E1265 from Genway Biotech
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ACE Antibody (FITC) - GWB-10E2A3 from Genway Biotech
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Goat anti-Mouse ACE/CD143 Polyclonal antibody, Biotin-Conjugated - DPABY-689 from Creative Diagnostics
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ACE, Monoclonal Antibody - MBS530328 from MyBioSource
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Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) - PAA004Mu01 from Cloud-clone
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Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) - PAA004Mu02 from Cloud-clone
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