| Gene Symbol |
Ace
|
| Entrez Gene |
11421
|
| Alt Symbol |
AW208573, CD143
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
|
| Other Description |
angiotensin-converting enzyme|dipeptidyl carboxypeptidase I|dipeptidyl peptidase|kininase II
|
| Swissprots |
P09470 Q6GTS2 P22967
|
| Accessions |
AAA37151 AAP03650 EDL34253 EDL34254 EDL34255 P09470 AK087056 BAC39791 AK154632 BAE32728 AK161020 BAE36151 AK164780 BC034367 AAH34367 BC040404 AAH40404 BC052531 AAH52531 BC083109 AAH83109 BC110362 AAI10363 BY197083 BY210311 J03940 AAA37146 J04946 AAA37147 J04947 AAA37148 M55333 AAA37149 NM_001281819 NP_001268748 NM_009598 NP_033728 NM_207624 NP_997507
|
| Function |
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm. {ECO:0000269|PubMed:15665832, ECO:0000269|PubMed:7753170, ECO:0000269|PubMed:8642790}.
|
| Subcellular Location |
Angiotensin-converting enzyme, soluble form: Secreted {ECO:0000250}.
|
| Tissue Specificity |
Testis-specific isoform is expressed in spermatocytes, adult testis.
|
| Top Pathways |
Hypertrophic cardiomyopathy (HCM), Chagas disease (American trypanosomiasis), Renin-angiotensin system
|