| Gene Symbol | CHMP4B |
|---|---|
| Entrez Gene | 128866 |
| Alt Symbol | C20orf178, CHMP4A, CTPP3, CTRCT31, SNF7, SNF7-2, Shax1, VPS32B, Vps32-2, dJ553F4.4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | charged multivesicular body protein 4B |
| Other Description | SNF7 homolog associated with Alix 1|Snf7 homologue associated with Alix 1|charged multivesicular body protein 4b|chromatin modifying protein 4B|chromatin-modifying protein 4b|hSnf7-2|hVps32-2|vacuolar protein sorting-associated protein 32-2|vacuolar protein-sorting-associated protein 32-2 |
| Swissprots | Q9H444 E1P5N4 Q53ZD6 |
| Accessions | EAW76293 EAW76294 Q9H444 AB100261 BAC79375 AY329085 AAQ91194 AY726594 BC033859 AAH33859 BQ926070 BU150721 CT001913 NM_176812 NP_789782 |
| Function | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, |
| Subcellular Location | Cytoplasm, cytosol. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. |
| Tissue Specificity | Widely expressed. Expressed at higher level in heart and skeletal muscle. Also expressed in brain, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes. {ECO:0000269|PubMed:14678797}. |
| Top Pathways | Endocytosis |