CHMP4B

Gene Symbol	CHMP4B
Entrez Gene	128866
Alt Symbol	C20orf178, CHMP4A, CTPP3, CTRCT31, SNF7, SNF7-2, Shax1, VPS32B, Vps32-2, dJ553F4.4
Species	Human
Gene Type	protein-coding
Description	charged multivesicular body protein 4B
Other Description	SNF7 homolog associated with Alix 1|Snf7 homologue associated with Alix 1|charged multivesicular body protein 4b|chromatin modifying protein 4B|chromatin-modifying protein 4b|hSnf7-2|hVps32-2|vacuolar protein sorting-associated protein 32-2|vacuolar protein-sorting-associated protein 32-2
Swissprots	Q9H444 E1P5N4 Q53ZD6
Accessions	EAW76293 EAW76294 Q9H444 AB100261 BAC79375 AY329085 AAQ91194 AY726594 BC033859 AAH33859 BQ926070 BU150721 CT001913 NM_176812 NP_789782
Function	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities,
Subcellular Location	Cytoplasm, cytosol. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Tissue Specificity	Widely expressed. Expressed at higher level in heart and skeletal muscle. Also expressed in brain, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes. {ECO:0000269|PubMed:14678797}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CHMP4A Antibody Blocking Peptide - LS-E22632 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHMP4B Antibody Blocking Peptide - LS-E19254 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHMP4B Antibody Blocking Peptide - LS-E19255 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHMP4B Antibody Blocking Peptide - LS-E10179 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CHMP4A Protein - NBP1-78875 from Novus Biologicals Category Protein Prices $269.00 Sizes 10 µg Source E. coli Species Human

CHMP4A Recombinant Protein - P4906 from Novus Biologicals Category Protein Prices $549.00 Sizes 10 µg Species Human

CHMP4B-Antibody-N-term-Blocking-Peptide - BP9528a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CHMP4B Protein - GTX109564-pro from GeneTex Category Protein Prices $299.00 Sizes 10 μg Source E. coli Species Human

Human CHMP4A protein - orb168114 from Biorbyt Category Protein Prices $230.00, $442.00, $1,666.00 Sizes 1 μg, 5 μg, 50 μg Source E.coli Species Human

CHMP4A Blocking Peptide - 33R-10321 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CHMP4B Blocking Peptide - 33R-8000 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CHMP4B Blocking Peptide - 33R-2366 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CHMP4B fusion protein - Ag4544 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human CHMP4B, GST-tagged - CHMP4B-11187H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Charged multivesicular body protein 4b(CHMP4B) - CSB-YP887976HU CSB-EP887976HU CSB-BP887976HU CSB-MP887976HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CHMP4B Protein - abx164339 from Abbexa Category Protein Species Human, Mouse, Rat

CHMP4B - TP307637 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

CHMP4B Recombinant Protein Antigen - NBP1-91782PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CHMP4A Recombinant Protein Antigen - NBP2-49557PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

CHMP4B Recombinant Protein Antigen - NBP2-49018PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

CHMP4A Peptide, Human - M34GP03105H from Creative Peptides Category Peptide Source Synthetic. Species Human

CHMP4B Peptide, Human - M34GP03106H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human CHMP4B protein - orb54475 from Biorbyt Category Protein Prices $289.00, $408.00, $476.00, $765.00, $1,275.00, $2,023.00 Sizes 10 μg, 50 μg, 100 μg, 200 μg, 500 μg, 1 mg Species Human

Charged multivesicular body protein 4b (CHMP4B), Recombinant Protein - MBS1394364 from MyBioSource Category Protein Prices $305.00, $580.00, $950.00, $950.00, $1,170.00, $1,170.00, $1,390.00, $1,390.00, $1,850.00, $1,850.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 50 µg (Baculovirus), 500 µg (E-Coli), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

CHMP4B Recombinant Protein (Human) (OPCA04962) - OPCA04962 from Aviva Systems Biology Category Protein Species Human

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