| Gene Symbol |
Ska3
|
| Entrez Gene |
219114
|
| Alt Symbol |
F630043A04Rik
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
spindle and kinetochore associated complex subunit 3
|
| Other Description |
spindle and kinetochore-associated protein 3
|
| Swissprots |
Q149T5 Q8C263 Q149T6
|
| Accessions |
EDL36162 EDL36163 Q8C263 AK089223 BAC40798 AK138255 AK158142 AK166171 AK199129 AK213217 AK217625 BC117500 AAI17501 BC117501 AAI17502 XM_006518859 XP_006518922 XR_383169 NM_198605 NP_941007
|
| Function |
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. {ECO:0000250}.
|
