Gene Symbol | Ska3 |
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Entrez Gene | 219114 |
Alt Symbol | F630043A04Rik |
Species | Mouse |
Gene Type | protein-coding |
Description | spindle and kinetochore associated complex subunit 3 |
Other Description | spindle and kinetochore-associated protein 3 |
Swissprots | Q149T5 Q8C263 Q149T6 |
Accessions | EDL36162 EDL36163 Q8C263 AK089223 BAC40798 AK138255 AK158142 AK166171 AK199129 AK213217 AK217625 BC117500 AAI17501 BC117501 AAI17502 XM_006518859 XP_006518922 XR_383169 NM_198605 NP_941007 |
Function | Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. {ECO:0000250}. |
Ska3 siRNA (m) - sc-144992 from Santa Cruz Biotechnology
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Ska3 shRNA Plasmid (m) - sc-144992-SH from Santa Cruz Biotechnology
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Ska3 shRNA (m) Lentiviral Particles - sc-144992-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU005171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN30879 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30879 from Sigma-Aldrich
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SKA3 siRNA (Mouse) - CRN2261 from Cohesion Biosciences
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SKA3 - MBS8223945 from MyBioSource
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shRNA set against Mouse F630043A04Rik (NM_198605.3) - SHH288501 from Creative biogene
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Mouse SKA3 siRNA - orb291736 from Biorbyt
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SKA3 shRNA Plasmid (Mouse) - CHN2261 from Cohesion Biosciences
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SKA3 miRNA 3'UTR clone - MiUTR1M-04541 from Creative biogene
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