IL22RA1

Gene Symbol IL22RA1
Entrez Gene 58985
Alt Symbol CRF2-9, IL22R, IL22R1
Species Human
Gene Type protein-coding
Description interleukin 22 receptor, alpha 1
Other Description IL-22 receptor subunit alpha-1|IL-22R-alpha-1|IL-22RA1|cytokine receptor class-II member 9|cytokine receptor family 2 member 9|interleukin-22 receptor subunit alpha-1|zcytoR11
Swissprots Q9HB22 B2R9Y9 A8K839 Q8N6P7
Accessions EAW95111 Q8N6P7 AF286095 AAG22073 AK226001 AK292204 BAF84893 AK304454 BAG65271 AK308522 AK313971 BAG36686 BC014096 BC029273 AAH29273 JF432213 ADZ15430 XM_011541882 XP_011540184 NM_021258 NP_067081
Function Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. {ECO:0000269|PubMed:11035029, ECO:0000269|PubMed:11564763, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:12351624, ECO:0000269|PubMed:12941841, ECO:0000269|PubMed:17204547}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. {ECO:0000269|PubMed:12407026, ECO:0000269|PubMed:15308104, ECO:0000269|PubMed:17828272, ECO:0000269|PubMed:17900301, ECO:0000269|PubMed:18061474}.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

Human IL22 Receptor Alpha protein fragment - ab132009 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE stained with Coomassie Blue showing ab132009 at approximately 86.9 kDa.

Human IL22 Receptor Alpha protein fragment - ab163699 from Abcam

Category Protein
Source Wheat germ
Species Human
ab163699 on a 12.5% SDS-PAGE stained with Coomassie Blue.

IL22 Receptor Alpha peptide - ab6227 from Abcam

Category Peptide

IL22 Receptor Alpha peptide - ab6229 from Abcam

Category Peptide

IL22RA1 / IL22R Antibody Blocking Peptide - LS-E6388 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

IL22RA1 / IL22R Antibody Blocking Peptide - LS-E17921 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

IL22RA1 / IL22R Antibody Blocking Peptide - LS-E17920 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

IL22RA1 / IL22R Antibody Blocking Peptide - LS-E29974 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

IL22RA1 / IL22R Antibody Blocking Peptide - LS-E29978 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

Recombinant Human IL-22 R alpha 1 Protein - H00058985-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

IL-22 R alpha 1 Recombinant Protein - H00058985-P01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

IL-22 R alpha 1 Peptide - NBP1-76455PEP from Novus Biologicals

Category Peptide
Prices $149.00
Sizes 50 µg
Species Human

IL-22 R alpha 1 Blocking Peptide - NBP1-76724PEP from Novus Biologicals

Category Peptide
Prices $129.00
Sizes 50 µg
Species Human

IL22RA1-Antibody-C-term-Blocking-Peptide - BP19114b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Recombinant Human IL-22 R alpha 1, CF - 2770-LR-050 from R&D Systems

Category Protein
Source Mouse myeloma cell line, NS0-derived, Pro18-Thr228, with a C-terminal 6-His tag

Human IL22RA1 protein - orb246265 from Biorbyt

Category Protein
Prices $340.00, $629.00, $1,003.00, $1,556.00
Sizes 50 μg, 200 μg, 500 μg, 1 mg
Species Human

Human IL-22 RA1 protein - orb180318 from Biorbyt

Category Protein
Prices $289.00, $400.00, $1,326.00, $1,981.00
Sizes 10 μg, 50 μg, 500 μg, 1 mg
Source Human Cells
Species Human

Human IL22R Protein - abx067507 from Abbexa

Category Protein
Source E.coli
Species Human

IL22RA1 / IL22R - H00058985-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

IL22RA1 / IL22R - H00058985-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

IL22RA1 / IL22R - H00058985-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

IL22RA1 / IL22R - H00058985-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

IL22RA1 / IL22R Control Peptide - AP30416CP-N from Acris Antibodies

Category Peptide
Prices $135.00
Sizes 50 µg

IL22RA1 / IL22R Control Peptide - AP30417CP-N from Acris Antibodies

Category Peptide
Prices $135.00
Sizes 50 µg

Interleukin 22 Receptor (IL22R), Human - 20-8983 from ARP American Research Products

Category Protein
Prices $469.00
Sizes 50 µg
Source E.coli
Species Human
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