Gene Symbol | IL22RA1 |
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Entrez Gene | 58985 |
Alt Symbol | CRF2-9, IL22R, IL22R1 |
Species | Human |
Gene Type | protein-coding |
Description | interleukin 22 receptor, alpha 1 |
Other Description | IL-22 receptor subunit alpha-1|IL-22R-alpha-1|IL-22RA1|cytokine receptor class-II member 9|cytokine receptor family 2 member 9|interleukin-22 receptor subunit alpha-1|zcytoR11 |
Swissprots | Q9HB22 B2R9Y9 A8K839 Q8N6P7 |
Accessions | EAW95111 Q8N6P7 AF286095 AAG22073 AK226001 AK292204 BAF84893 AK304454 BAG65271 AK308522 AK313971 BAG36686 BC014096 BC029273 AAH29273 JF432213 ADZ15430 XM_011541882 XP_011540184 NM_021258 NP_067081 |
Function | Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. {ECO:0000269|PubMed:11035029, ECO:0000269|PubMed:11564763, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:12351624, ECO:0000269|PubMed:12941841, ECO:0000269|PubMed:17204547}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. {ECO:0000269|PubMed:12407026, ECO:0000269|PubMed:15308104, ECO:0000269|PubMed:17828272, ECO:0000269|PubMed:17900301, ECO:0000269|PubMed:18061474}. |
Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
Human IL22 Receptor Alpha protein fragment - ab132009 from Abcam
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Human IL22 Receptor Alpha protein fragment - ab163699 from Abcam
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IL22 Receptor Alpha peptide - ab6227 from Abcam
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IL22 Receptor Alpha peptide - ab6229 from Abcam
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IL22RA1 / IL22R Antibody Blocking Peptide - LS-E6388 from LifeSpan Bioscience
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IL22RA1 / IL22R Antibody Blocking Peptide - LS-E17921 from LifeSpan Bioscience
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IL22RA1 / IL22R Antibody Blocking Peptide - LS-E17920 from LifeSpan Bioscience
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IL22RA1 / IL22R Antibody Blocking Peptide - LS-E29974 from LifeSpan Bioscience
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IL22RA1 / IL22R Antibody Blocking Peptide - LS-E29978 from LifeSpan Bioscience
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Recombinant Human IL-22 R alpha 1 Protein - H00058985-Q01 from Novus Biologicals
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IL-22 R alpha 1 Recombinant Protein - H00058985-P01 from Novus Biologicals
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IL-22 R alpha 1 Peptide - NBP1-76455PEP from Novus Biologicals
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IL-22 R alpha 1 Blocking Peptide - NBP1-76724PEP from Novus Biologicals
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IL22RA1-Antibody-C-term-Blocking-Peptide - BP19114b from Abgent, a WuXi AppTec company
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Recombinant Human IL-22 R alpha 1, CF - 2770-LR-050 from R&D Systems
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Human IL22RA1 protein - orb246265 from Biorbyt
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Human IL-22 RA1 protein - orb180318 from Biorbyt
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Human IL22R Protein - abx067507 from Abbexa
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IL22RA1 / IL22R - H00058985-P01-10 from Acris Antibodies
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IL22RA1 / IL22R - H00058985-P01-25 from Acris Antibodies
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IL22RA1 / IL22R - H00058985-Q01-10 from Acris Antibodies
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IL22RA1 / IL22R - H00058985-Q01-25 from Acris Antibodies
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IL22RA1 / IL22R Control Peptide - AP30416CP-N from Acris Antibodies
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IL22RA1 / IL22R Control Peptide - AP30417CP-N from Acris Antibodies
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Interleukin 22 Receptor (IL22R), Human - 20-8983 from ARP American Research Products
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