IL22RA1
| Gene Symbol | IL22RA1 |
|---|---|
| Entrez Gene | 58985 |
| Alt Symbol | CRF2-9, IL22R, IL22R1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 22 receptor, alpha 1 |
| Other Description | IL-22 receptor subunit alpha-1|IL-22R-alpha-1|IL-22RA1|cytokine receptor class-II member 9|cytokine receptor family 2 member 9|interleukin-22 receptor subunit alpha-1|zcytoR11 |
| Swissprots | Q9HB22 B2R9Y9 A8K839 Q8N6P7 |
| Accessions | EAW95111 Q8N6P7 AF286095 AAG22073 AK226001 AK292204 BAF84893 AK304454 BAG65271 AK308522 AK313971 BAG36686 BC014096 BC029273 AAH29273 JF432213 ADZ15430 XM_011541882 XP_011540184 NM_021258 NP_067081 |
| Function | Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. {ECO:0000269|PubMed:11035029, ECO:0000269|PubMed:11564763, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:12351624, ECO:0000269|PubMed:12941841, ECO:0000269|PubMed:17204547}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. {ECO:0000269|PubMed:12407026, ECO:0000269|PubMed:15308104, ECO:0000269|PubMed:17828272, ECO:0000269|PubMed:17900301, ECO:0000269|PubMed:18061474}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
IL-22Rα1 CRISPR/Cas9 KO Plasmid (h) - sc-404104 from Santa Cruz Biotechnology
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IL-22Rα1 HDR Plasmid (h) - sc-404104-HDR from Santa Cruz Biotechnology
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IL-22Rα1 Double Nickase Plasmid (h) - sc-404104-NIC from Santa Cruz Biotechnology
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IL-22Rα1 Double Nickase Plasmid (h2) - sc-404104-NIC-2 from Santa Cruz Biotechnology
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IL-22Rα1 CRISPR Activation Plasmid (h) - sc-404104-ACT from Santa Cruz Biotechnology
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IL-22Rα1 CRISPR Activation Plasmid (h2) - sc-404104-ACT-2 from Santa Cruz Biotechnology
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IL-22Rα1 Lentiviral Activation Particles (h) - sc-404104-LAC from Santa Cruz Biotechnology
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IL-22Rα1 Lentiviral Activation Particles (h2) - sc-404104-LAC-2 from Santa Cruz Biotechnology
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IL-22Rα1 siRNA (h) - sc-88174 from Santa Cruz Biotechnology
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IL-22Rα1 shRNA Plasmid (h) - sc-88174-SH from Santa Cruz Biotechnology
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IL-22Rα1 shRNA (h) Lentiviral Particles - sc-88174-V from Santa Cruz Biotechnology
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IL-22 R alpha 1 RNAi - H00058985-R02 from Novus Biologicals
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MISSION® esiRNA - EHU030581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10610 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10610 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07672 from Sigma-Aldrich
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IL22RA1 siRNA (Human) - CRJ1754 from Cohesion Biosciences
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IL22RA1 - MBS8210136 from MyBioSource
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shRNA set against Human IL22RA1 (NM_021258.3) - SHH318725 from Creative biogene
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IL22RA1 shRNA Plasmid (Human) - CHJ1754 from Cohesion Biosciences
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IL22RA1 miRNA 3'UTR clone - MiUTR3H-07690 from Creative biogene
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