IL22RA1

Gene Symbol IL22RA1
Entrez Gene 58985
Alt Symbol CRF2-9, IL22R, IL22R1
Species Human
Gene Type protein-coding
Description interleukin 22 receptor, alpha 1
Other Description IL-22 receptor subunit alpha-1|IL-22R-alpha-1|IL-22RA1|cytokine receptor class-II member 9|cytokine receptor family 2 member 9|interleukin-22 receptor subunit alpha-1|zcytoR11
Swissprots Q9HB22 B2R9Y9 A8K839 Q8N6P7
Accessions EAW95111 Q8N6P7 AF286095 AAG22073 AK226001 AK292204 BAF84893 AK304454 BAG65271 AK308522 AK313971 BAG36686 BC014096 BC029273 AAH29273 JF432213 ADZ15430 XM_011541882 XP_011540184 NM_021258 NP_067081
Function Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. {ECO:0000269|PubMed:11035029, ECO:0000269|PubMed:11564763, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:12351624, ECO:0000269|PubMed:12941841, ECO:0000269|PubMed:17204547}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. {ECO:0000269|PubMed:12407026, ECO:0000269|PubMed:15308104, ECO:0000269|PubMed:17828272, ECO:0000269|PubMed:17900301, ECO:0000269|PubMed:18061474}.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

IL-22Rα1 (G-20) - sc-168173 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IL-22Rα1 (G-20): sc-168173. Western blot analysis of IL-22Rα1 expression in non-transfected: sc-117752 (A) and human IL-22Rα1 transfected: sc-114543 (B) 293T whole cell lysates.

IL-22Rα1 (3-RE40) - sc-134366 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
IL-22Rα1 (3-RE40): sc-134366. Western blot analysis of IL-22Rα1 expression in human IL-22Rα1 transfected (A) and non-transfected (B) 293T whole cell lysates.

Anti-IL22 Receptor Alpha antibody - ab5984 from Abcam

Prices $394.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of IL-22R expression in human HepG2 cell lysate with ab5984 at 1µg /ml.

Anti-IL22 Receptor Alpha antibody - ab18568 from Abcam

Prices $378.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ab18568 employed for the immunohistochemical detection of human N-terminal IL22 receptor, in paraffin embedded human spleen.

Anti-IL22 Receptor Alpha antibody - ab167213 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
FACS analysis of negative control 293 cells (Black) and IL22RA1 expressing 293 cells (Green) using IL22RA1 purified mouse polyclonal antibody ab167213 diluted 1μg/ml.

Anti-IL22 Receptor Alpha antibody - ab5982 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of IL-22R expression in human HepG2 cell lysate with ab5982 at 1 µg /ml.

Anti-IL22 Receptor Alpha antibody - ab98917 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-IL22 Receptor Alpha antibody (ab98917) at 1 µg/ml + Human fetal kidney cell lysate at 10 µg

Anti-IL22 Receptor Alpha antibody - C-terminal - ab138949 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-IL22 Receptor Alpha antibody - C-terminal (ab138949) at 1/100 dilution + K562 cell lysate at 35 µg

Anti-IL22RA1 / IL22R Antibody (aa42-70) - LS-C83981 from LifeSpan Bioscience

Prices $455.00
Sizes 200 µg
Host Goat
Clonality Polyclonal

Anti-IL22RA1 / IL22R Antibody (aa18-228, clone 12K118, PerCP) - LS-C182892 from LifeSpan Bioscience

Prices $605.00
Sizes 100 tst
Host Rat
Clonality Monoclonal
Clone 12K118

Anti-IL22RA1 / IL22R Antibody (aa408-436, AP) - LS-C260142 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL22RA1 / IL22R Antibody (aa408-436, APC) - LS-C260143 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL22RA1 / IL22R Antibody (aa408-436, Biotin) - LS-C260144 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL22RA1 / IL22R Antibody (aa408-436, Azide-free, HRP) - LS-C260145 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL22RA1 / IL22R Antibody (aa408-436, PE) - LS-C260147 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL22RA1 / IL22R Antibody (aa408-436, FITC) - LS-C260146 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL22RA1 / IL22R Antibody (aa560-574) - LS-C406 from LifeSpan Bioscience

Prices $325.00, $890.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot of IL-22R expression in human HepG2 cell lysate with IL-22R antibody at 1 ug /ml.

Anti-IL22RA1 / IL22R Antibody (aa267-565, Biotin) - LS-C301026 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL22RA1 / IL22R Antibody (aa267-565, FITC) - LS-C303552 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL22RA1 / IL22R Antibody - LS-C308463 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-IL22RA1 / IL22R Antibody - LS-C308466 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-IL22RA1 / IL22R Antibody (aa251-300) - LS-C108016 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IL22RA1 / IL22R antibody LS-C108016 Western blot of Fetal Kidney lysate.

Anti-IL22RA1 / IL22R Antibody (C-Terminus) - LS-C111238 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IL22RA1 / IL22R antibody LS-C111238 Western blot of Transfected 293T cell lysate.

Anti-IL22RA1 / IL22R Antibody (aa408-436) - LS-C322218 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL22RA1 / IL22R Antibody - LS-C310758 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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