NPC2

Gene Symbol NPC2
Entrez Gene 10577
Alt Symbol EDDM1, HE1
Species Human
Gene Type protein-coding
Description Niemann-Pick disease, type C2
Other Description Niemann-Pick disease type C2 protein|epididymal protein 1|epididymal secretory protein E1|human epididymis-specific protein 1|tissue-specific secretory protein
Swissprots B4DQV7 P61916
Accessions EAW81176 EAW81177 EAW81178 P61916 AK222474 BAD96194 AK298975 BAG61069 AK300879 BAG62522 AK311931 BAG34872 BC002532 AAH02532 DQ891907 ABM82833 DQ895093 ABM86019 X67698 CAA47928 NM_006432 NP_006423
Function Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport. {ECO:0000269|PubMed:17018531, ECO:0000269|PubMed:18772377, ECO:0000
Subcellular Location Secreted {ECO:0000269|PubMed:19723497}. Endoplasmic reticulum {ECO:0000269|PubMed:19723497}. Lysosome {ECO:0000269|PubMed:19723497}.
Tissue Specificity Epididymis. {ECO:0000269|PubMed:19664597}.
Top Pathways Lysosome

NPC2 (D-3) - sc-166449 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NPC2 (D-3): sc-166449. Western blot analysis of NPC2 expression in non-transfected 293T: sc-117752 (A), mouse NPC2 transfected 293T: sc-122109 (B) and NIH/3T3 (C) whole cell lysates.

NPC2 (H-125) - sc-33776 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NPC2 (H-125): sc-33776. Western blot analysis of NPC2 expression in non-transfected: sc-117752 (A) and mouse NPC2 transfected: sc-122109 (B) 293T whole cell lysates.

NPC2 (H-10) - sc-166321 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NPC2 (H-10): sc-166321. Western blot analysis of NPC2 expression in Hep G2 whole cell lysate.

NPC2 (I-14) - sc-30349 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NPC2 (M-15) - sc-21470 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NPC2 (M-15): sc-21470. Western blot analysis of NPC2 expression in non-transfected: sc-117752 (A) and mouse NPC2 transfected: sc-122108 (B) 293T whole cell lysates.

NPC2 (S-13) - sc-30346 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NPC2 (S-13): sc-30346. Western blot analysis of NPC2 expression in NIH/3T3 (A), Caki-1 (B), KNRK (C) and Hep G2 (D) whole cell lysates.

NPC2 (V-16) - sc-30347 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Niemann Pick C2 antibody - ab186829 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung tissue labelling Niemann Pick C2 with ab186829 at 1/200. Magnification: 400x.

Anti-Niemann Pick C2 antibody - ab92736 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Niemann Pick C2 antibody (ab92736) at 1 µg/ml + Testis (Human) Tissue Lysate - adult normal tissue (ab30257) at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Niemann Pick C2 antibody - ab126190 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Niemann Pick C2 antibody (ab126190) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

Anti-Niemann Pick C2 antibody - ab64183 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Niemann Pick C2 antibody (ab64183) at 1 µg/ml + Testis (Human) Tissue Lysate - adult normal tissue (ab30257) at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Niemann Pick C2 antibody - ab77453 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-Niemann Pick C2 antibody (ab77453) at 5 µg/ml + immunogen at 0.2 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

Anti-Niemann Pick C2 antibody - ab67958 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Niemann Pick C2 antibody (ab67958) at 1/500 dilutionLane 1 : Niemann Pick C2 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-NPC2 Antibody - LS-C334047 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human lung using NPC2 antibody at dilution of 1:200 (400x lens).

Anti-NPC2 Antibody - LS-C341613 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NPC2 Antibody (aa18-31) - LS-C112961 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
NPC2 antibody (0.5 ug/ml) staining of Human Testis lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-NPC2 Antibody (aa18-30) - LS-C139762 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
NPC2 antibody (0.1 ug/ml) staining of Mouse Kidney lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-NPC2 Antibody (clone 1F4) - LS-C139240 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F4
Immunoprecipitation of NPC2 transfected lysate using anti-NPC2 monoclonal antibody and Protein A Magnetic Bead.

Anti-NPC2 Antibody - LS-C155292 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded U87 xenograft, using NPC2 antibody at 1:500 dilution.

Niemann-Pick type C2 Antibody - NBP1-84012 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Niemann-Pick type C2 Antibody [NBP1-84012] - Analysis in human cell line RT-4.

Niemann-Pick type C2 Antibody - NBP2-15044 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Niemann-Pick type C2 Antibody [NBP2-15044] - Protein at cytoplasm on lung carcinoma.

Niemann-Pick type C2 Antibody (4B9) - H00010577-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4B9

Niemann-Pick type C2 Antibody - H00010577-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: Niemann-Pick type C2 Antibody [H00010577-B01P] - Analysis of NPC2 expression in NIH/3T3.

Niemann-Pick type C2 Antibody - H00010577-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Niemann-Pick type C2 Antibody [H00010577-D01P] - Analysis of NPC2 expression in mouse lung.

Niemann-Pick type C2 Antibody - NBP1-52028 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Search more