NPC2

Gene Symbol	NPC2
Entrez Gene	10577
Alt Symbol	EDDM1, HE1
Species	Human
Gene Type	protein-coding
Description	Niemann-Pick disease, type C2
Other Description	Niemann-Pick disease type C2 protein|epididymal protein 1|epididymal secretory protein E1|human epididymis-specific protein 1|tissue-specific secretory protein
Swissprots	B4DQV7 P61916
Accessions	EAW81176 EAW81177 EAW81178 P61916 AK222474 BAD96194 AK298975 BAG61069 AK300879 BAG62522 AK311931 BAG34872 BC002532 AAH02532 DQ891907 ABM82833 DQ895093 ABM86019 X67698 CAA47928 NM_006432 NP_006423
Function	Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport. {ECO:0000269|PubMed:17018531, ECO:0000269|PubMed:18772377, ECO:0000
Subcellular Location	Secreted {ECO:0000269|PubMed:19723497}. Endoplasmic reticulum {ECO:0000269|PubMed:19723497}. Lysosome {ECO:0000269|PubMed:19723497}.
Tissue Specificity	Epididymis. {ECO:0000269|PubMed:19664597}.
Top Pathways	Lysosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NPC2 ELISA Kit (Sandwich ELISA) - LS-F9488 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 0.78 ng/ml Range 0.78-50 ng/ml

Human NPC2 ELISA Kit - abx152544 from Abbexa Category ELISA Kit Sensitivity 0.31 ng/ml Range 0.781 ng/ml - 50 ng/ml

Epididymal secretory protein E1 (NPC2), Human, ELISA Kit - CSB-EL015976HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Epididymal secretory protein E1 (NPC2), Human, ELISA Kit - E01E0392 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Niemann Pick Disease Type C2 (NPC2), Human, ELISA Kit - SEL139Hu from ARP American Research Products Category ELISA Kit Prices $790.00 Sizes 96 t Sensitivity 0.31ng/mL Range 0.78-50ng/mL

NPC2 (Human) IP-WB Antibody Pair - H00010577-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

NPC2 (Human) Matched Antibody Pair - H00010577-AP51 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

NPC2 (Human) Matched Antibody Pair - H00010577-AP61 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Epididymal secretory protein E1, ELISA Kit - MBS280371 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Epididymal secretory protein E1 (NPC2), ELISA Kit - MBS7213318 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Epididymal secretory protein E1 (NPC2), ELISA Kit - MBS7202079 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Epididymal secretory protein E1 (NPC2), ELISA Kit - MBS7225435 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Epididymal secretory protein E1 (NPC2), ELISA Kit - MBS7211886 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Epididymal secretory protein E1 (NPC2), ELISA Kit - MBS7216242 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Epididymal secretory protein E1 (NPC2), ELISA Kit - MBS7220608 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Epididymal secretory protein E1 (NPC2), ELISA Kit - MBS7210906 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Epididymal secretory protein E1 (NPC2), ELISA Kit - MBS7244199 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Epididymal secretory protein E1 (NPC2), ELISA Kit - MBS7204802 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Epididymal secretory protein E1 (NPC2), ELISA Kit - MBS7250645 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Epididymal secretory protein E1 (NPC2), ELISA Kit - MBS7237369 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Epididymal secretory protein E1 (NPC2), ELISA Kit - MBS7206139 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Niemann-Pick disease, type C2, ELISA Kit - MBS909574 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.078 ng/ml Range 0.312 ng/ml-20 ng/ml

ELISA Kit for Niemann Pick Disease Type C2 (NPC2) - SEL139Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.31ng/mL. Range 0.781-50ng/mL The standard curve concentrations used for the ELISA’s were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL, 0.781ng/mL

Human Epididymal secretory protein E1(NPC2) ELISA kit - CSB-EL015976HU from Cusabio Category ELISA Kit Sensitivity 0.078ng/ml Range 0.312 ng/ml-20 ng/ml

ELISA Kit for Niemann Pick Disease Type C2 (NPC2) - SEL139Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.31ng/mL. Range 0.781-50ng/mL The standard curve concentrations used for the ELISA's were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL, 0.781ng/mL

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