NPC2

Gene Symbol	NPC2
Entrez Gene	10577
Alt Symbol	EDDM1, HE1
Species	Human
Gene Type	protein-coding
Description	Niemann-Pick disease, type C2
Other Description	Niemann-Pick disease type C2 protein|epididymal protein 1|epididymal secretory protein E1|human epididymis-specific protein 1|tissue-specific secretory protein
Swissprots	B4DQV7 P61916
Accessions	EAW81176 EAW81177 EAW81178 P61916 AK222474 BAD96194 AK298975 BAG61069 AK300879 BAG62522 AK311931 BAG34872 BC002532 AAH02532 DQ891907 ABM82833 DQ895093 ABM86019 X67698 CAA47928 NM_006432 NP_006423
Function	Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport. {ECO:0000269|PubMed:17018531, ECO:0000269|PubMed:18772377, ECO:0000
Subcellular Location	Secreted {ECO:0000269|PubMed:19723497}. Endoplasmic reticulum {ECO:0000269|PubMed:19723497}. Lysosome {ECO:0000269|PubMed:19723497}.
Tissue Specificity	Epididymis. {ECO:0000269|PubMed:19664597}.
Top Pathways	Lysosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Niemann Pick C2 full length protein - ab132688 from Abcam Category Protein Source Wheat germ Species Human

Human Niemann Pick C2 full length protein - ab200499 from Abcam Category Protein Source HEK 293 cells Species Human

Human Niemann Pick C2 peptide - ab93308 from Abcam Category Peptide

Human Niemann Pick C2 peptide - ab93309 from Abcam Category Peptide

Human Niemann Pick C2 protein fragment - ab153100 from Abcam Category Protein Source Wheat germ Species Human

NPC2 Antibody Blocking Peptide - LS-E27640 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NPC2 Antibody Blocking Peptide - LS-E27330 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Niemann-Pick type C2 Protein - H00010577-P01 from Novus Biologicals Category Protein Prices $319.00, $369.00, $529.00 Sizes 2 µg, 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Niemann-Pick type C2 Protein - H00010577-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NPC2-Antibody-C-term-Blocking-Peptide - BP6755b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NPC2 blocking peptide - GTX88174-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Niemann Pick C2 Peptide - AC21-2154-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NPC2 - H00010577-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

NPC2 - H00010577-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NPC2 - H00010577-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NPC2 Peptide - 42-795P from ProSci Category Peptide Species Human

Npc2 Peptide - 42-456P from ProSci Category Peptide Species Mouse

HE1 Recombinant Protein - 96-561 from ProSci Category Protein Prices $375.00 Sizes 100 µg Source HEK293 cells Species Human

NPC2 fusion protein - ag13719 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human NPC2, His-tagged - NPC2-162H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human NPC2, His-tagged - NPC2-349H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Niemann Pick Disease Type C2 (NPC2) - RPL139Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Human Niemann-Pick disease type C2 / NPC2 Protein (His Tag) - 13341-H08H-100 from Sino Biological Category Protein Prices $138.00, $348.00 Sizes 20 µg, 100 µg Source Human Cells Species Human

Recombinant Niemann Pick Disease Type C2 (NPC2) - RPL139Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Epididymal secretory protein E1(NPC2) - CSB-YP015976HU CSB-EP015976HU CSB-BP015976HU CSB-MP015976HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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