| Gene Symbol | Prkcg |
|---|---|
| Entrez Gene | 24681 |
| Alt Symbol | PKC, PKCI, Prkc, Prkcc, RATPKCI |
| Species | Rat |
| Gene Type | protein-coding |
| Description | protein kinase C, gamma |
| Other Description | PKC-gamma|protein kinase C gamma type|protein kinase C type I (gamma type) |
| Swissprots | P63319 Q5FWS3 |
| Accessions | AAA41873 EDL84948 P63319 BC089226 AAH89226 M13707 AAA41874 X07287 CAA30267 XM_006228014 XP_006228076 NM_012628 NP_036760 |
| Function | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but ma |
| Subcellular Location | Cytoplasm {ECO:0000250|UniProtKB:P63318}. Cytoplasm, perinuclear region. Cell membrane {ECO:0000269|PubMed:12471040, ECO:0000269|PubMed:14688616}; Peripheral membrane protein. Cell junction, synapse, synaptosome {ECO:0000269|PubMed:14688616}. Cell projection, dendrite {ECO:0000269|PubMed:10336135}. Note=Translocates to synaptic membranes on stimulation. {ECO:0000269|PubMed:14688616}. |
| Top Pathways | Inflammatory mediator regulation of TRP channels, Oxytocin signaling pathway, Thyroid hormone synthesis, Retrograde endocannabinoid signaling, MicroRNAs in cancer |